Bi-directional and temporal relationship between elevated alanine aminotransferase and hypertension in a longitudinal study of Chinese adults. (17th November 2021)

• Record Type: Journal Article
• Authors: Huang, Guoxin; Zhou, Hui; Shen, Chao; Sheng, Yihui; Xue, Ruyu; Dong, Chen; Zhang, Shaoyan
• Is Part Of: Clinical and experimental hypertension. Volume 43:Number 8(2021)
• Page Start: 750
• Page End: 757
• Publication Date: 2021-11-17
• Subjects: Bi-directional association -- temporal sequence -- alanine aminotransferase -- hypertension; Hypertension -- Chemotherapy -- Periodicals; Hypotensive agents -- Periodicals; 616.132
• DOI: 10.1080/10641963.2021.1960364
• Languages: English
• ISSNs: 1064-1963

Abstract

ABSTRACT: Objective: Despite the strong correlation between elevated alanine aminotransferase (ALT) and hypertension, their bi-directional and temporal relationship are currently unclear. Our study aimed to explore the bi-directional and temporal association between elevated ALT (ALT > 40 U/L) and hypertension. Methods: Measurements of alanine aminotransferase and blood pressure were obtained twice from 2013 to 2017 in 3314 Chinese adults without cardiovascular disease at baseline. Bi-directional and cross-lagged panel analyses were performed to dissect the temporal relationship between elevated ALT and hypertension. Results: Longitudinally, we found that baseline elevated ALT was strongly correlated with incident hypertension (odds ratios = 2.16, P = .001), and baseline hypertension was also significantly associated with incident elevated ALT (odds ratios = 1.64, P = .026). The cross-lagged path coefficients from baseline ALT to follow-up blood pressure were significantly greater than that from baseline blood pressure to follow-up ALT ( β : 0.043 vs. 0.026, P < .05 for systolic blood pressure and β : 0.052 vs. 0.024, P < .05 for diastolic blood pressure). Conclusion: Our results provide evidence for the bi-directional association of elevated ALT and hypertension among Chinese adults, and elevated ALT probably antedates the development of hypertension.