Biomarker Prediction of Postoperative Healing of Diabetic Foot Ulcers: A Retrospective Observational Study of Serum Albumin. Issue 4 (July 2021)

• Record Type: Journal Article
• Authors: Cheng, Pu; Dong, Yunxian; Hu, Zhicheng; Huang, Shaobin; Cao, Xiaoling; Wang, Peng; Xu, Hailin; Zhu, Jiayuan; Tang, Bing
• Is Part Of: Journal of WOCN. Volume 48:Issue 4(2021)
• Publication Date: 2021-07
• Subjects: Albumin -- Diabetic foot ulcer -- Preoperative evaluation -- Wound healing; Abdomen -- Surgery -- Periodicals; Abdomen -- Wounds and injuries -- Nursing -- Periodicals; Bedsores -- Nursing -- Periodicals; Fecal incontinence -- Nursing -- Periodicals; Enterostomy -- Nursing -- Periodicals; Urinary incontinence -- Nursing -- Periodicals; 610.73
• DOI: 10.1097/WON.0000000000000780
• Languages: English
• ISSNs: 1071-5754

Abstract

Abstract : PURPOSE: The purpose of this study was to investigate the relationship and to determine potential usefulness of serum albumin as a biomarker for predicting postoperative diabetic foot ulcer (DFU) healing. DESIGN: A retrospective study. SUBJECTS AND SETTING: The sample comprised 266 inpatients with type 2 diabetes receiving care in The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. Among them, 174 had DFUs and underwent surgery for foot DFUs including amputation, skin grafting, and flap procedures. A comparison group consisted of 92 inpatients without a DFU or surgery. METHODS: The association between healing and preoperative albumin levels was analyzed via a logistic regression model and receiver operating characteristic (ROC) curve. RESULTS: The albumin value of patients with DFU grade 3 or more (3.23 ± 0.58 g/dL) was lower than that of patients with DFU grade 1-2 (3.58 ± 0.5 g/dL), and both were lower than that of the comparison group (3.89 ± 0.3 g/dL). Patients with a DFU with hypoalbuminemia (<3.5 g/dL) had a 2.5-fold higher risk of nonhealing at postoperative 28 days than patients with normal levels (odds ratio = 3.51; 95% confidence interval, 1.75-7.06; P < .001). For patients with a DFU overall, the ROC curve showed a preoperative albumin cutoff of 3.44 g/dL for DFU wound healing. CONCLUSIONS: For patients with a DFU undergoing surgery, preoperative serum albumin may be used as a biomarker for predicting postoperative healing. Abstract : The NCPD test for this article is available online only at the journal website, jwocnonline.com, and the test can be taken online at NursingCenter.com.