Inherent Mosaicism and Extensive Mutation of Human Placentas. Issue 6 (June 2021)

• Record Type: Journal Article
• Authors: Coorens, Tim H. H.; Oliver, Thomas R. W.; Sanghvi, Rashesh; Sovio, Ulla; Cook, Emma; Vento-Tormo, Roser; Haniffa, Muzlifah; Young, Matthew D.; Rahbari, Raheleh; Sebire, Neil; Campbell, Peter J.; Charnock-Jones, D. Stephen; Smith, Gordon C. S.; Behjati, Sam
• Is Part Of: Obstetrical & gynecological survey. Volume 76:Issue 6(2021)
• Publication Date: 2021-06
• Subjects: Obstetrics -- Periodicals; Gynecology -- Periodicals; Generative organs, Female -- Surgery -- Periodicals; 618
• DOI: 10.1097/OGX.0000000000000935
• Languages: English
• ISSNs: 0029-7828

Abstract

Abstract : (Abstracted from Nature 2021;592:80–85) Approximately 1% to 2% of pregnancies involve chromosomal aberrations confined to the placenta. During the first few days of embryogenesis when fetal and placental lineages diverge, clonal expansion and mosaicism may occur, representing a potential pathological divergence from normal clonal dynamics of early embryogenesis.