SARS-CoV-2 Cardiac Involvement in Young Competitive Athletes. Issue 4 (27th July 2021)

• Record Type: Journal Article
• Authors: Moulson, Nathaniel; Petek, Bradley J.; Drezner, Jonathan A.; Harmon, Kimberly G.; Kliethermes, Stephanie A.; Patel, Manesh R.; Baggish, Aaron L.; Asif, Irfan M.; Borchers, James; Edenfield, Katherine M.; Emery, Michael S.; Goerl, Kyle; Hainline, Brian; Kim, Jonathan H.; Kraus, William E.; Lampert, Rachel; Leiszler, Matthew; Levine, Benjamin D.; Martinez, Matthew W.; O'Connor, Francis G.; Phelan, Dermot; Rink, Lawrence D.; Taylor, Herman A.; Ade, Carl; Aiyer, Aryan; Alfadhli, Jarrah; Amaradio, Chloe; Anderson, Scott; Arlis-Mayor, Stephanie; Aubry, Jonathan S.; Austin, Andrea; Beaver, Timothy; Benitez, Nicolas; Berkstresser, Brant; Best, Thomas M.; Bohon, Tiffany; Bonnet, Jonathan P.; Boyington, Elizabeth; Bray, James; Bryant, Jenna; Carnahan, Sean; Chamberlain, Rachel; Charters, Samantha; Churchill, Timothy W.; Comeau, Douglas; Cook, Laura E.; Corey, Deanna; Costa, Amy; Crowther, Marshall; Dalia, Tarun; Davidson, Craig; Davitt, Kaitlin; De St Maurice, Annabelle; Dean, Peter N.; DeZenzo, Katelyn; Dimitris, Courtney; Doperak, Jeanne; Duffaut, Calvin; Fafara, Craig; Fahy, Katherine; Ferderber, Jason; Finn, Megan; Galante, Angelo; Gerlt, Todd; Gest, Amy; Gilson, Carla; Goldberger, Jeffrey; Goldman, Joshua; Groezinger, Erich; Guin, Jonathan R.; Halseth, Heather; Hare, Joshua; Harness, Beth; Hatamiya, Nicolas; Haylett, Julie; Hazen, Neal; Hiroi, Yeun; Hockenbrock, Amy; Honsvall, Amanda; Hopp, Jennifer; Howard, Julia; Huba, Samantha; Husaini, Mustafa; Huston, Lindsay; Hwang, Calvin; Irvin, Laura; Gene Iven, Val; Jones, Robert; Joyce, Donald; Karlson, Kristine; Klein, Christian; Klenck, Chris; Kirk, Michele; Knight, Jordan; Knippa, Laura; Knutson, Madeleine; Kovacs, Louis E.; Kuscher, Yumi; Kussman, Andrea; Landreth, Chrissy; Leu, Amy; Lothian, Dylan; Lowery, Maureen; Lukjanczuk, Andrew; MacKnight, John M.; Magee, Lawrence M.; Magnuson, Marja-Liisa; Mares, Aaron V.; Marquez, Anne; McKinley, Grant; Meier, Megan; Miles, Christopher; Miller, Emily; Miller, Hannah; Mitrani, Raul; Myerburg, Robert J.; Mytyk, Greg; Narver, Andrew; Nattiv, Aurelia; Nur, Laika; Organ, Brooke E.; Pendergast, Meredith; Pettrone, Frank A.; Poddar, Sourav K.; Priestman, Diana; Quinn, Ian; Reifsteck, Fred; Restivo, Morgan; Robinson, James B.; Roe, Ryan; Rosamond, Thomas; Rubertino Shearer, Carrie; Rueda, Miguel; Sakamoto, Takamasa; Schnebel, Brock; Shah, Ankit B.; Shahtaji, Alan; Shannon, Kevin; Sheridan-Young, Polly; Statuta, Siobhan M.; Stovak, Mark; Tarsici, Andrei; Taylor, Kenneth S.; Terrell, Kim; Thomason, Matt; Tso, Jason; Vigil, Daniel; Wang, Francis; Winningham, Jennifer; Zorn, Susanna T.;
• Is Part Of: Circulation. Volume 144:Issue 4(2021)
• Publication Date: 2021-07-27
• Subjects: athletes -- COVID-19 -- myocarditis -- return to sport -- SARS-CoV-2; Blood -- Circulation -- Periodicals; Cardiovascular system -- Periodicals; Cardiology -- Periodicals; Heart -- Diseases -- Periodicals; Blood Circulation; Cardiovascular System; Vascular Diseases; 616.1
• DOI: 10.1161/CIRCULATIONAHA.121.054824
• Languages: English
• ISSNs: 0009-7322

Abstract

Abstract : Background: Cardiac involvement among hospitalized patients with severe coronavirus disease 2019 (COVID-19) is common and associated with adverse outcomes. This study aimed to determine the prevalence and clinical implications of COVID-19 cardiac involvement in young competitive athletes. Methods: In this prospective, multicenter, observational cohort study with data from 42 colleges and universities, we assessed the prevalence, clinical characteristics, and outcomes of COVID-19 cardiac involvement among collegiate athletes in the United States. Data were collected from September 1, 2020, to December 31, 2020. The primary outcome was the prevalence of definite, probable, or possible COVID-19 cardiac involvement based on imaging definitions adapted from the Updated Lake Louise Imaging Criteria. Secondary outcomes included the diagnostic yield of cardiac testing, predictors for cardiac involvement, and adverse cardiovascular events or hospitalizations. Results: Among 19 378 athletes tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, 3018 (mean age, 20 years [SD, 1 year]; 32% female) tested positive and underwent cardiac evaluation. A total of 2820 athletes underwent at least 1 element of cardiac triad testing (12-lead ECG, troponin, transthoracic echocardiography) followed by cardiac magnetic resonance imaging (CMR) if clinically indicated. In contrast, primary screening CMR was performed in 198 athletes. Abnormal findings suggestive of SARS-CoV-2 cardiac involvement were detected by ECG (21 of 2999 [0.7%]), cardiac troponin (24 of 2719 [0.9%]), and transthoracic echocardiography (24 of 2556 [0.9%]). Definite, probable, or possible SARS-CoV-2 cardiac involvement was identified in 21 of 3018 (0.7%) athletes, including 15 of 2820 (0.5%) who underwent clinically indicated CMR (n=119) and 6 of 198 (3.0%) who underwent primary screening CMR. Accordingly, the diagnostic yield of CMR for SARS-CoV-2 cardiac involvement was 4.2 times higher for a clinically indicated CMR (15 of 119 [12.6%]) versus a primary screening CMR (6 of 198 [3.0%]). After adjustment for race and sex, predictors of SARS-CoV-2 cardiac involvement included cardiopulmonary symptoms (odds ratio, 3.1 [95% CI, 1.2, 7.7]) or at least 1 abnormal triad test result (odds ratio, 37.4 [95% CI, 13.3, 105.3]). Five (0.2%) athletes required hospitalization for noncardiac complications of COVID-19. During clinical surveillance (median follow-up, 113 days [interquartile range=90 146]), there was 1 (0.03%) adverse cardiac event, likely unrelated to SARS-CoV-2 infection. Conclusions: SARS-CoV-2 infection among young competitive athletes is associated with a low prevalence of cardiac involvement and a low risk of clinical events in short-term follow-up. Abstract : Supplemental Digital Content is available in the text.