18F-FDG and 68Ga-FAPI PET/CT in the Evaluation of Ground-Glass Opacity Nodule. (May 2021)

• Record Type: Journal Article
• Authors: Chen, Haojun; Pang, Yizhen; Meng, Tinghua; Yu, Xiuyi; Sun, Long
• Is Part Of: Clinical nuclear medicine. Volume 46:Number 5(2021)
• Publication Date: 2021-05
• Subjects: 18F-FDG -- 68Ga-FAPI -- ground-glass opacity -- low-dose CT -- PET/CT; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000003600
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract : Abstract: A 50-year-old woman with a newly detected pulmonary ground-glass opacity (GGO) nodule underwent PET/CT to determine the likelihood of malignancy. This patient was enrolled in the prospective study (NCT04588064) to determine the effectiveness of 18 F-FDG and 68 Ga-FAPI PET/CT for characterization of the GGO nodule. On PET/CT images, minimal 18 F-FDG uptake but intense 68 Ga-FAPI uptake was observed in this GGO nodule. This patient subsequently underwent video-assisted thoracoscopic surgery, and postoperative pathological examination confirmed the diagnosis of invasive adenocarcinoma. This case presented an example where 68 Ga-FAPI PET/CT showed higher tracer uptake than 18 F-FDG in the malignant GGO nodule.