Skeletal Muscle Nrf2 Contributes to Exercise-Evoked Systemic Antioxidant Defense Via Extracellular Vesicular Communication. Issue 3 (July 2021)

• Record Type: Journal Article
• Authors: Gao, Lie; Wang, Han-Jun; Tian, Changhai; Zucker, Irving H.
• Is Part Of: Exercise and sport sciences reviews. Volume 49:Issue 3(2021)
• Publication Date: 2021-07
• Subjects: Nrf2 -- antioxidants -- exosomes -- extracellular vesicles -- cardiac protection; Sports -- Physiological aspects -- Periodicals; Exercise -- Physiological aspects -- Periodicals; Sports medicine -- Periodicals; 612.76
• DOI: 10.1249/JES.0000000000000257
• Languages: English
• ISSNs: 0091-6331

Abstract

Abstract : This review explores the hypothesis that the repetitive contraction-relaxation that occurs during chronic exercise activates skeletal myocyte nuclear factor erythroid-derived 2-like 2 (Nrf2) to upregulate antioxidant enzymes. These proteins are secreted into the circulation within extracellular vesicles and taken up by remote cells, thus providing remote organs with cytoprotection against subsequent oxidative stress. Abstract : We hypothesize that exercise training protects remote tissues by exosomal transport of antioxidant proteins dependent on skeletal muscle Nrf2.