Cimetidine and ranitidine: comparison of effects on hepatic drug metabolism. Issue 6243 (20th September 1980)

• Record Type: Journal Article
• Authors: Henry, D A; Macdonald, I A; Kitchingman, G; Bell, G D; Langman, M J
• Is Part Of: BMJ. Volume 281:Issue 6243(1980)
• Page Start: 775
• Page End: 777
• Publication Date: 1980-09-20
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Medicine; Periodicals; 610
• DOI: 10.1136/bmj.281.6243.775
• Languages: English
• ISSNs: 0007-1447

Abstract

Abstract : Paired studies of hepatic microsomal function were conducted in eight subjects during treatment with two histamine H2 antagonists, cimetidine and ranitidine. Cimetidine but not ranitidine inhibited the metabolism of antipyrine (phenazone) and demethylation of aminopyrine (aminophenazone) as measured by breath 14CO2 production after intravenous injection of 14C-aminopyrine. These results suggest that the metabolic inhibitory actions on the liver may be separated from H2 antagonist effects, and that ranitidine has an advantage over cimetidine by not inhibiting microsomal drug oxidative function.