Relationship between serum uric acid level and nonalcoholic fatty liver disease in type 2 diabetes patients. Issue 33 (20th August 2021)

• Record Type: Journal Article
• Authors: Yu, Haifeng; Zhao, Ling; Liu, Lijuan; Li, Yanfang; Sun, Jing; Liu, Youde
• Other Names: Kumar. Ritesh section editor.
• Is Part Of: Medicine. Volume 100:Issue 33(2021)
• Publication Date: 2021-08-20
• Subjects: insulin resistance -- nonalcoholic fatty liver disease -- serum uric acid -- type 2 diabetes; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000026946
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract : Abstract: This study aimed to investigate the association between serum uric acid (SUA) level and nonalcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes (T2DM). T2DM patients hospitalized in the Department of Hepatology, Yantai Qishan Hospital, between April 2012 and December 2018 were classified into the NAFLD group and the non-NAFLD group. Clinical data, glucose and lipid metabolism biomarkers, and liver and kidney function parameters were retrospectively collected. Five hundred eighty-three T2DM patients met the inclusion and exclusion criteria; 227 patients were included in the non-NAFLD group and 356 patients were included in the NAFLD group. Multiple linear regression analyses showed that SUA was positively correlated with body mass index ( P = .003), triglycerides ( P = .009), aspartate aminotransferase ( P = .036), and alanine aminotransferase ( P = .038) and negatively correlated with estimated glomerular filtration rate ( P < .001) in T2DM patients. Multivariate regression analyses demonstrated that after adjusting for confounding factors, the SUA tertile was still significantly associated with NAFLD occurrence in T2DM patients ( P for trend = .008). With reference to SUA tertile I, the odds ratios for NAFLD in the SUA tertile II and tertile III groups were 1.729 (95% confidence interval [CI]: 1.086–2.753) and 2.315 (95% CI: 1.272–4.213), respectively. The level of SUA in T2DM patients was associated with the occurrence of NAFLD. Elevated SUA was associated with a significantly increased prevalence of NAFLD. The SUA level was an independent risk factor for NAFLD occurrence in patients with T2DM.