Metastatic nonclear renal cell carcinoma current review in evolving treatment strategies. Issue 3 (May 2021)

• Record Type: Journal Article
• Authors: Suárez, Cristina; Díaz-Mejía, Nely; Morales-Barrera, Rafael; González, Macarena; Mateo, Joaquin; Carles, Joan
• Is Part Of: Current opinion in urology. Volume 31:Issue 3(2021)
• Publication Date: 2021-05
• Subjects: immunotherapy -- MET inhibitors -- nonclear cell renal cell carcinoma -- papillary renal cell carcinoma; Urology -- Periodicals; Review Literature -- Bibliography; Review Literature -- Periodicals; Male Urogenital Diseases -- Bibliography; Male Urogenital Diseases -- Periodicals; Female Urogenital Diseases -- Bibliography; Female Urogenital Diseases -- Periodicals; Urologic Diseases -- Bibliography; Urologic Diseases -- Periodicals; Periodicals; 616.6005
• DOI: 10.1097/MOU.0000000000000869
• Languages: English
• ISSNs: 1473-6586

Abstract

Abstract : Purpose of review: Renal cell carcinoma (RCC) is the 6th most often diagnosed cancer in men and the 10th in women. Nearly 75% of the renal cancer cases are clear cell histologic subtype, whereas nonclear cell histologies represent the remaining 25%. Treatment options for clear renal type are well established. However, as nonclear RCC represents a heterogenous and less frequent group. Current treatment options for these tumors are limited and mostly based on evidence derived from small phase II clinical trials. The present review aims to provide an update of the available treatment options for nonclear RCC. Recent findings: In the past decade, the vascular endothelial growth factor tyrosine kinase inhibitor, sunitinib, and mammalian target of rapamycin inhibitors, everolimus, and temsirolimus, have demonstrated limited efficacy in nonclear RCC. Recent studies with MET inhibitors and immunotherapy-based combinations have proven promising activity, especially in certain subgroups of patients, such as patients with MET-driven disease or patients with sarcomatoid features RCC. Summary: Here, we report currently available data about biology and treatment of nonclear cell RCC.