HYPERREFLECTIVITY ON OPTICAL COHERENCE TOMOGRAPHY IN MACULAR TELANGIECTASIA TYPE 2. Issue 7 (July 2021)

• Record Type: Journal Article
• Authors: Tzaridis, Simone; Hess, Kristina; Heeren, Tjebo F. C.; Bonelli, Roberto; Holz, Frank G.; Friedlander, Martin
• Is Part Of: Retina. Volume 41:Issue 7(2021)
• Publication Date: 2021-07
• Subjects: hyperreflectivity -- MacTel -- macular telangiectasia type 2 -- neovascularization -- optical coherence tomography -- optical coherence tomography angiography -- retinal imaging; Retina -- Diseases -- Periodicals; Retinal Diseases; Vitreous Body; 617.735
• DOI: 10.1097/IAE.0000000000003111
• Languages: English
• ISSNs: 0275-004X

Abstract

Abstract : Purpose: To define, characterize, and classify hyperreflectivity on optical coherence tomography and report its prevalence in macular telangiectasia Type 2. Methods: In a primary cross-sectional analysis, multimodal imaging data were retrospectively analyzed. The definition of hyperreflectivity and neovascularization on optical coherence tomography followed optical coherence tomography angiography–based criteria. Eyes were graded for the presence of hyperreflectivity and neovascularization and further categorized into three classes based on position and extent of hyperreflectivity. In a secondary analysis, eyes were reviewed for ≥24 months using optical coherence tomography imaging. Results: Three hundred and twenty-two eyes from 161 patients were analyzed in the cross-sectional analysis. Hyperreflectivity was found in 177 (55%) and neovascular membranes in 49 (15%) eyes. Hyperreflectivity correlated significantly with parameters indicative of disease progression. In the longitudinal analysis, 206 eyes from 103 patients were reviewed over a mean of 35.6 months. 17/86 eyes (20%) showed a de novo development of hyperreflectivity. 8/29 eyes (28%) with preexistent intraretinal hyperreflectivity developed outer retinal hyperreflectivity. A high proportion of eyes with outer retinal hyperreflectivity (17/52 [33%]) developed neovascular membranes. Conclusion: Hyperreflectivity represents a common finding in macular telangiectasia Type 2 but lacks a uniform definition. We propose a hyperreflectivity grading scale that may help to estimate disease progression and identify eyes at risk for developing neovascular membranes. Abstract : We define and classify hyperreflectivity on optical coherence tomography in macular telangiectasia Type 2. We report prevalence data for hyperreflectivity and demonstrate its role as marker of disease progression. We identify hyperreflective changes preceding the development of secondary neovascularizations and propose optical coherence tomography angiography–based criteria for detecting neovascular membranes on B-scan optical coherence tomography.