A Highly Sensitive Electrochemiluminescence Spermine Biosensor Based on Au−Ag Bimetallic Nanoclusters. Issue 9 (28th July 2021)

• Record Type: Journal Article
• Authors: Guo, Yongliang; Tian, Lili; Wu, Jiangming; Wu, Yang; Liu, Yongmei; Du, Jie; Lu, Xiaoquan
• Is Part Of: Electroanalysis. Volume 33:Issue 9(2021)
• Page Start: 2016
• Page End: 2024
• Publication Date: 2021-07-28
• Subjects: Biogenic amine -- Spermine -- Au−Ag bimetallic nanoclusters -- Conductive hydrogel -- Electrochemiluminescence; Electrochemical analysis -- Periodicals; Chemistry, Analytical -- Periodicals; Electrochemistry -- Periodicals; 543.4
• DOI: 10.1002/elan.202100169
• Languages: English
• ISSNs: 1040-0397

Abstract

Abstract: In this study, we found that spermine (SPM) could enhance electrochemiluminescence (ECL) intensity of Au−Ag bimetallic nanoclusters (Au−Ag BNCs) with triethylamine (TEA) as a co‐reactant. An ECL sensor was fabricated to detect SPM, which contained Au−Ag BNCs as ECL emitters and conductive hydrogel containing polyaniline‐amino trimethylene phosphonic acid (PANI‐ATMP) as an immobilizing matrix. The increased ECL intensity of SPM was linear with the logarithm of concentrations of SPM in the range of 1 pM to 10 μM with high selectivity, excellent stability, and the limit of detection is 0.11 pM (S/N=3). This sensor realized the detection of SPM in urine samples, which was fast and economic, possessing potential applications for SPM detection in clinical and bioanalysis. Abstract :