Estimation of renal function by three CKD-EPI equations in Chinese HIV/AIDS patients: A STROBE-compliant article. Issue 22 (4th June 2021)

• Record Type: Journal Article
• Authors: Zhao, Naxin; Zeng, Zhili; Liang, Hongyuan; Wang, Fang; Yang, Di; Xiao, Jiang; Chen, Meiling; Zhao, Hongxin; Zhang, Fujie; Gao, Guiju
• Other Names: Musio. Franco section editor.
• Is Part Of: Medicine. Volume 100:Issue 22(2021)
• Publication Date: 2021-06-04
• Subjects: cystatin C -- glomerular filtration rate -- human immunodeficiency virus/acquired immune deficiency syndrome -- serum creatinine; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000026003
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract : Abstract: Assessing renal function accurately is important for human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS) patients. Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) recommended three equations to calculate estimated glomerular filtration rate (eGFR). There is evidence that eGFR based on the combination of serum creatinine and cystatin C is the most accurate of the three equations. But there is limited data on the comparison of three CKD-EPI equations in Chinese HIV/AIDS patients. The aim of our study was to compare the three CKD-EPI equations in Chinese HIV/AIDS population and assess renal function. Cross-sectional, single center, prospective study. One hundred seventy two Chinese adult HIV/AIDS patients were enrolled, including 145 (84.3%) males and 27 (15.7%) females. Mean age was 40(±12) years old. Overall mean eGFR based on serum creatinine, cystatin C and the combination of the 2 markers was 112.6(±19.0) mL/min/1.73 m 2, 92.0(±24.2)mL/min/1.73 m 2, and 101.7(±21.8)mL/min/1.73 m 2, respectively ( P = .000). The eGFR calculated by serum creatinine alone is higher than eGFR calculated by combination of serum creatinine and cystatin C, and eGFR calculated by cystatin C individual is lower than eGFR calculated by combination of the 2 markers. Of the 3 CKD-EPI equations, the CKD-EPIscr-cys equation may have the most accuracy in evaluating renal function in Chinese HIV/AIDS patients while the CKD-EPIscr equation may overestimate renal function and the CKD-EPIcys equation may underestimate renal function.