Perioperative omega-3 fatty acids for liver surgery: A meta-analysis of randomized controlled trials. Issue 27 (9th July 2021)

• Record Type: Journal Article
• Authors: Xiao, Fubin; Han, Wei; Yue, Qing; Ke, Jianji; Jia, Baoxing; Fu, Xiaojuan
• Other Names: Augustin. Goran section editor.
• Is Part Of: Medicine. Volume 100:Issue 27(2021)
• Publication Date: 2021-07-09
• Subjects: liver surgery -- omega-3 fatty acids -- randomized controlled trials; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000025743
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract: Introduction: The effect of perioperative omega-3 fatty acids for liver surgery remained controversial. We conducted a systematic review and meta-analysis to explore the influence of omega-3 fatty acids versus placebo in patients undergoing liver surgery. Methods: We have searched PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases through May 2020, and included randomized controlled trials (RCTs) assessing the effect of omega-3 fatty acids versus placebo for liver surgery. This meta-analysis was performed using the random-effect model. Results: Five RCTs were included in the meta-analysis. Overall, compared with control group for liver surgery, omega-3 fatty acids were associated with substantially reduced incidence of infection (odd ratio [OR]=0.56; 95% confidence interval [CI] =0.34–0.91; P = .02), but revealed no remarkable influence on complications (OR = 0.60; 95% CI = 0.29–1.24; P = .17), mortality (OR = 0.76; 95% CI = 0.06–9.37; P = .83), liver failure (OR = 0.72; 95% CI = 0.10 to 5.00; P = 0.74), biliary leakage (OR=1.24; 95% CI = 0.41 to 3.76; P = .70), bleeding (OR = 1.76; 95% CI = 0.63–4.95; P = .28), or ileus (OR = 0.39; 95% CI = 0.07–2.05; P = .27). Conclusion: Perioperative omega-3 fatty acids may be beneficial to reduce the incidence of infection after liver surgery.