Cone parameters in different vision levels from the adaptive optics imaging. Issue 16 (23rd April 2021)

• Record Type: Journal Article
• Authors: Cheng, Huanhuan; Ciuffreda, Kenneth J.; Jiang, Huilu; Zhou, Kun; Lin, Sigeng; Zheng, Jingwei; Yu, Xinping; Vasudevan, Balamurali; Liang, Yuanbo
• Other Names: Palazón-Bru. Antonio section editor.
• Is Part Of: Medicine. Volume 100:Issue 16(2021)
• Publication Date: 2021-04-23
• Subjects: adaptive optics -- cone density -- cone spacing -- parafovea -- visual resolution; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000025618
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract : Abstract: To investigate the relationship between visual resolution and cone parameters in eyes with different levels of best corrected visual acuity (BCVA). Seventeen eyes of 10 volunteers with BCVA of 20/12.5 or better (group 1) and 16 eyes of 10 volunteers with BCVA of 20/16 (group 2) were investigated in the study. Images of the cone photoreceptors at 1.5 ° from the fovea were obtained using an adaptive optics (AO) retinal camera. The BCVA was obtained following a subjective refraction using a standardized logMAR visual acuity chart. The mean cone density (29, 570.96 ± 2489.94 cells/mm 2 ) at 1.5° from the fovea in group 1 (BCVA ≥ 20/12.5, n = 17) was significantly greater ( P < .001) than that (22, 963.59 ± 2987.92 cells/mm 2 ) in group 2 (BCVA = 20/16, n = 16). The cone spacing at 1.5 ° from the fovea in group 1 was 6.45 ± 0.28 μm (mean ± SD), which was significantly smaller ( P < .001) than 7.36 ± 0.50 μm (mean ± SD) in group 2. In the stepwise regression analysis, greater angular cone density (odds ratio [OR], 4.48; P = .005) and smaller angular cone spacing (OR, 0.60; P = .007) at 1.5 ° from the fovea were significantly associated with the better BCVA. The greater cone density and smaller cone spacing at the parafovea were found in eyes with BCVA of 20/12.5 or better, as compared to that in eyes with BCVA of 20/16. Knowledge of cone distribution for different BCVA levels may be beneficial for different clinical conditions.