Association between NEAT1 polymorphism and the risk of lung cancer: A protocol for systematic review and meta-analysis. Issue 16 (23rd April 2021)

• Record Type: Journal Article
• Authors: Hu, Zhongbao; Chen, Jingsheng; Meng, Ping; Li, Ming
• Is Part Of: Medicine. Volume 100:Issue 16(2021)
• Publication Date: 2021-04-23
• Subjects: long non-coding RNA -- lung cancer -- meta-analysis -- nuclear paraspeckle assembly transcript 1 -- polymorphism -- protocol; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000025478
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract: Background: Long noncoding RNAs play vital roles in development and progression of lung cancers. Nuclear paraspeckle assembly transcript 1 (NEAT1) polymorphisms were reported to be closely related to lung cancer susceptibility. Recently, numerous studies have been performed to detect the association between NEAT1 polymorphisms and lung cancer susceptibility. However, their results were inconsistent and controversial. So, we carried out a meta-analysis aiming to define the association exactly. Methods: Appropriate studies were retrieved from searching Web of Science, PubMed, Scopus, and Google scholar databases, updated January 31, 2021. The pooled odds ratios with 95% confidence intervals were calculated to estimate the strength of the association between NEAT1 polymorphisms and lung cancer risk. All of the data were analyzed with Stata 16.0. Results: The results of this meta-analysis will be submitted to a peer-reviewed journal for publication. Conclusion: This meta-analysis will summarize the relationship between NEAT1 polymorphism and lung cancer.