Kidney injury biomarkers during exposure to tenofovir-based preexposure prophylaxis. (1st June 2021)

• Record Type: Journal Article
• Authors: Nickolas, Thomas L.; Barasch, Jonathan; Mugwanya, Kenneth K.; Branch, Andrea D.; Heffron, Renee; Wanga, Valentine; Mugo, Nelly R.; Ronald, Allan; Celum, Connie; Donnell, Deborah; Baeten, Jared M.; Wyatt, Christina M.
• Is Part Of: AIDS. Volume 35:Number 7(2021)
• Publication Date: 2021-06-01
• Subjects: AIDS (Disease) -- Periodicals; Acquired Immunodeficiency Syndrome; AIDS (Disease); Periodicals; Periodicals; 616.9792005
• DOI: 10.1097/QAD.0000000000002865
• Languages: English
• ISSNs: 0269-9370

Abstract

Abstract : N/A: We previously reported a higher incidence of non-albumin proteinuria and a small but significant decline in estimated glomerular filtration rate (eGFR) among HIV-negative adults randomized to emtricitabine/tenofovir disoproxil fumarate preexposure prophylaxis (FTC/TDF PrEP) versus placebo. In a nested case--control study among participants randomized to FTC/TDF PrEP, established kidney injury biomarkers measured at 12 months were not significantly different between participants who subsequently experienced one of these kidney endpoints and randomly selected controls who did not.