Risk Factors of SARS-CoV-2 Antibodies in Arapahoe County First Responders—The COVID-19 Arapahoe SErosurveillance Study (CASES) Project. Issue 3 (March 2021)

• Record Type: Journal Article
• Authors: Sabourin, Katherine R.; Schultz, Jonathan; Romero, Joshua; Lamb, Molly M.; Larremore, Daniel; Morrison, Thomas E.; Frazer-Abel, Ashley; Zimmer, Shanta; Kedl, Ross M.; Jaenisch, Thomas; Rochford, Rosemary
• Is Part Of: Journal of occupational and environmental medicine. Volume 63:Issue 3(2021)
• Publication Date: 2021-03
• Subjects: antibodies -- caseworker -- COVID-19 -- first responder -- firefighter -- police -- SARS-CoV-2; Medicine, Industrial -- Periodicals; Environmental health -- Periodicals; Occupational Medicine -- Periodicals; Environmental Medicine -- Periodicals; Environmental health; Medicine, Industrial; Periodicals; Electronic journals; 616.9803
• DOI: 10.1097/JOM.0000000000002099
• Languages: English
• ISSNs: 1076-2752

Abstract

Abstract : Objectives: Define the seroprevalence and risk factors for SARS-CoV-2 antibodies in Arapahoe County, Colorado first responders (eg, law enforcement, human services, fire departments). Methods: Two hundred sixty four first responders were enrolled June to July 2020. SARS-CoV-2 seropositivity was defined as detection of immunoglobulin G (IgG) antibodies to both spike receptor binding domain and nucleocapsid in venous blood by validated enzyme-linked immunosorbent assay. We compared risk factors for being seropositive versus seronegative. Results: 4% (11/264) were SARS-CoV-2 seropositive. Seropositive participants were significantly more likely to have lung disease (% seropositive, % seronegative; P -value) (36%, 8%; P = 0.01), prior SARS-CoV-2/COVID-19 testing (36%, 8%; P ⩽ 0.01), a prior positive result (18%, less than 1%), and to believe they previously had COVID-19 (64%, 15%; P < 0.01). Only 15% of those believing they had COVID-19 had anti-SARS-CoV-2 antibodies. Conclusions: Human services employees and individuals with lung disease are at SARS-CoV-2 exposure risk. Few individuals believed they had COVID-19 had prior exposure. Abstract : Supplemental Digital Content is available in the text