Proximal gastric vagotomy versus long-term maintenance treatment with cimetidine for chronic duodenal ulcer: a prospective randomised trial. Issue 6359 (8th January 1983)

• Record Type: Journal Article
• Authors: Gear, M W
• Is Part Of: BMJ. Volume 286:Issue 6359(1983)
• Page Start: 98
• Page End: 99
• Publication Date: 1983-01-08
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Medicine; Periodicals; 610
• DOI: 10.1136/bmj.286.6359.98
• Languages: English
• ISSNs: 0007-1447

Abstract

Abstract : Forty-four patients with chronic duodenal ulceration were allocated randomly to either long-term maintenance treatment with cimetidine or proximal gastric vagotomy. All were followed up both clinically and endoscopically for periods of one to four years. The rate of recurrence of ulcer during and after medical treatment was 54% while after surgery it was 10%. One patient developed severe allergic hepatitis while receiving maintenance treatment with cimetidine, and two others had to stop treatment because of possible drug reactions. Patients whose ulceration recurs while they are receiving treatment with cimetidine should be offered the possibility of operation.