Synergistic effect of combined oyster peptide and ginseng extracts on anti-exercise-fatigue and promotion of sexual interest activity in male ICR mice. (November 2021)

• Record Type: Journal Article
• Authors: Luo, Xianliang; Liu, Wangxin; Zhong, Hao; Yan, Yongqiu; Feng, Fengqin; Zhao, Minjie
• Is Part Of: Journal of functional foods. Volume 86(2021)
• Publication Date: 2021-11
• Subjects: Oyster peptide -- Ginseng extracts -- Synergistic effect -- Anti-fatigue -- Sexual function; CON control group -- OP 0.2 mg/g.bw of oyster peptide -- GE 0.2 mg/g.bw of ginseng extracts -- OPGE-L 0.1 mg/g.bw OP+GE -- OPGE-M 0.2 mg/g.bw OP+GE -- OPGE-H 0.6 mg/g.bw OP+GE -- BUN blood urea nitrogen -- LA lactic acid -- MDA malondialdehyde -- T-AOC total antioxidant capacity -- T testosterone -- LH luteinizing hormone -- FSH follicle-stimulating hormone -- E2 estradiol -- PRL prolactin -- PDE-5 phosphodiesterase-5 -- NO nitric oxide -- CYP17A1 cytochrome p450 17A1 -- StAR steroid acute regulatory protein -- HSD17B3 17β-hydroxysteroid dehydrogenase 3 -- CT Capture times -- ML Mounting latency -- MF Mounting frequency -- IL Intromission latency -- IF Intromission frequency -- EL Ejaculation latency -- EF Ejaculation frequency -- PEI Post-ejaculatory intervals -- HPLC high-performance liquid chromatography; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2021.104700
• Languages: English
• ISSNs: 1756-4646

Abstract

Graphical abstract: Highlights: Novelty, a synergistic effect of OPGE on anti-fatigue and sexual ability was explored. OPGE promoted physical recovery and accelerated fatigue elimination. OPGE increased sexual behavior of male mice after exhausted swimming. OPGE enhanced the expression of testosterone synthesis related protease. Abstract: Traditionally, ginseng and oyster are regarded as biological tonics for enhancing vital energy. In this study, a post-exercise fatigue model and copulatory test were performed to evaluate the effects of combined oyster peptide and ginseng extracts (OPGE) on anti-fatigue and sexual function. The forced swimming time of mice was prolonged by taking OPGE. Moreover, the level of serum lactic acid, blood urea nitrogen, and lactate dehydrogenase activity were decreased, while the liver glycogen content and antioxidant ability in skeletal muscles were increased. Furthermore, OPGE statistically improved the sexual behavioral indexes of exercise-fatigue mice. The levels of testosterone and follicle-stimulating hormone in serum, and the expression of testosterone synthesis-related-protease in testis were increased by OPGE administration, while phosphodiesterase-5 content was decreased. Overall, our study suggested that OPGE could be a potential androgen-like dietary supplement to accelerate the elimination of fatigue and improve testosterone-deficiency symptom after intensive training.