A multifunctional, one-step gas foaming strategy for antimicrobial silver nanoparticle-decorated 3D cellulose nanofiber scaffolds. (1st December 2021)

• Record Type: Journal Article
• Authors: Moon, Joon Yeon; Lee, Joshua; Hwang, Tae In; Park, Chan Hee; Kim, Cheol Sang
• Is Part Of: Carbohydrate polymers. Volume 273(2021)
• Publication Date: 2021-12-01
• Subjects: Multifunctional gas foaming -- 3D nanofibers -- Regenerated cellulose -- Silver nanoparticles -- Wound dressing; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2021.118603
• Languages: English
• ISSNs: 0144-8617

Abstract

Abstract: Creating nanoparticle-decorated nanofibers in a single step can greatly speed up and scale up the production of scaffolds for various applications. In this study, we report a facile multifunctional method for the simultaneous foaming and synthesis of silver nanoparticles-covered three-dimensional cellulose using sodium borohydride (NaBH4). The physicochemical properties of the 3D cellulose-Ag scaffold were evaluated and compared to 2D CA membranes, including morphology (porous 3D vs flat 2D), mechanical properties (22.72 vs <13 MPa Young's modulus), antibacterial effect (27 vs 0 mm zone of inhibition), and biocompatibility. The findings suggest that our method enables the scaffold to be easily manufactured—indicating it can be used to scale-up manufacturing processes—with high bioactivity, antibacterial effect, and biocompatibility, showing potential as a 3D structure production method for tissue engineering and other relevant applications. Highlights: A multifunctional method was employed to create AgNPs and gas-foam CE nanofibers. Ag-decorated nanofibrous scaffolds exhibited excellent antibacterial activity. 3D Ag-decorated nanofibrous scaffolds were biocompatible and mechanically stable. The described process can speed up and simplify processes for scaffold production.