Neo‐clerodane Diterpenoids with Hypoglycemic Effects in Vivo from the Aerial Parts of Salvia hispanica L. Issue 9 (4th August 2021)

• Record Type: Journal Article
• Authors: Fan, Min; Wang, Ting; Peng, Li‐Yan; Huang, Jun‐Shang; Wu, Xing‐De; Wang, He‐Yao; Zhao, Qin‐Shi
• Is Part Of: Chemistry & biodiversity. Volume 18:Issue 9(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-08-04
• Subjects: Salvia hispanica -- neo-clerodane diterpenoid -- salvihispin H -- type 2 diabetes mellitus; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Biodiversity -- Periodicals; 572
• DOI: 10.1002/cbdv.202100517
• Languages: English
• ISSNs: 1612-1872

Abstract

Abstract: A new neo ‐clerodane diterpenoid, salvihispin H (1 ), and six known ones (2 –7 ) were identified from the aerial parts of Salvia hispanica L. The structure and absolute configuration of 1 were elucidated by extensive analysis of spectroscopic ( 1 H, 13 C, and 2D NMR, and HR‐ESI‐MS) and single‐crystal X‐ray diffraction data. The anti‐diabetic effects of salvihispin H (1 ) and salvifaricin (2 ) were evaluated in diabetic db/db mice. The data showed that 1 and 2 could significantly reduce fasting blood glucose level and improve insulin resistance, and compound 1 exerted glucose‐lowering effect more quickly than metformin. In addition, 1 and 2 could also reduce serum TG level in db/db mice. These results demonstrated that compounds 1 and 2 could be considered as potent candidates for the therapy of type 2 diabetes mellitus (T2DM). Abstract :