SAT0706 End-stage organ failure in sarcoidosis: characterization and predictive factors in 1082 patients. (15th June 2017)

• Record Type: Journal Article
• Authors: Pérez-Alvarez, R; Kostov, B; González, A García; Torre, R Gόmez De La; Dupla, M Lopez; Escalante, B De; Alguacil, A; Chara, J; Velilla, J; Rascόn, J; Morillo, JS Garcia; Feijoo, C; Fonseca, E; Bonet, M; Callejas, JL; Red, G de la; Vuelta, AB Madroñero; Soler, C; Peral, E; Cerezo, JF Gόmez; Cruz, G; Perez, P; Rodríguez, S Fernández; Pinilla, B; Gato, A; Akasbi, M; Robles, A; Ojeda, I; Vives, MJ; Morcillo, C; Penadés, M; Vicente, M De; Ramos-Casals, M; Pallarés, L; Brito-Zerόn, P;
• Is Part Of: Annals of the rheumatic diseases. Volume 76(2017)Supplement 2
• Page Start: 1042
• Page End: 1042
• Publication Date: 2017-06-15
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/annrheumdis-2017-eular.3376
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Objectives: To characterize the main features at presentation of sarcoidosis associated with the development of end-stage organ failure in a large multicenter cohort of patients from Southern Europe. Methods: In January 2017, the Spanish National Registry of Sarcoidosis (SARCOGEAS-SEMI) included 1082 consecutive patients diagnosed with sarcoidosis according to the ATS/ERS/WASOG 1999 statement and extrathoracic involvement to the 2014 WASOG instrument. The development of end-stage organ failure was assessed at the last visit. Results: The cohort consisted of 618 (57%) women and 464 (43%) men, with a mean age at diagnosis of 47yrs. After a mean follow-up of 82 months, 90 (8%) patients developed end-stage organ failure, including respiratory failure (n=56), chronic renal failure (n=13), cardiac failure/permanent cardiac device (n=8) and liver cirrhosis (n=3). The following baseline features were associated with end-stage organ failure in the univariate analysis: patients born in Spain (p=0.008), a higher mean age at diagnosis (p<0.001) and a radiological stage III/IV (p<0.001) With respect to extrathoracic involvement, spleen (p=0.015), renal (p=0.001), cardiac (p=0.028) and bone marrow (p=0.003) involvements, hypercalcemia (p=0.018) and use of corticosteroids (p<0.001) were associated with end-stage organ failure, while patients with cutaneous sarcoidosis had a lower risk (p=0.029). Multivariate analysis identified age at diagnosis (OR 1.05), radiological stages III/IV (OR 3.12) and use of corticosteroids (OR 4.55) as independent variables associated with the development of end-stage organ failure. Conclusions: Nearly 10% of patients with sarcoidosis developed end-stage organ failure. Respiratory failure represented two thirds of cases of sarcoidosis-related organ failure, followed by renal (15% of cases) and cardiac (9%). Older patients, as well as those presenting with advanced radiological stages, had an enhanced risk of developing end-stage organ failure. Disclosure of Interest: None declared