P-010 A Study of the novel 054 Penumbra aspiration device in the ICA and MCA. (12th July 2011)

• Record Type: Journal Article
• Authors: Frei, D; Bellon, R; Huddle, D; Dooley, G; Gerber, J; Turk, A; Heck, D; Hui, F; Joseph, G; Jahan, R; Miskolczi, L; Carpenter, J; Grobelny, T; Goddard, J; Leader, B; Bose, A; Sit, S P
• Is Part Of: Journal of neurointerventional surgery. Volume 3(2011)Supplement 1
• Page Start: A20
• Page End: A20
• Publication Date: 2011-07-12
• Subjects: Nervous system -- Surgery -- Periodicals; Cerebrovascular disease -- Surgery -- Periodicals; 617.48
• DOI: 10.1136/neurintsurg-2011-010097.44
• Languages: English
• ISSNs: 1759-8478

Abstract

Abstract : Purpose: The 054 reperfusion catheter is a newly introduced component of the Penumbra System specifically designed to enhance aspiration efficiency by increasing the catheter diameter. The goal of this study was to compare its safety and effectiveness in reducing clot burden in the internal carotid artery (ICA) and the middle cerebral artery (MCA). Methods and Materials: This study was a retrospective case review of 74 consecutive patients at 11 international centers with ICA or MCA occlusion who were treated with the Penumbra System. All patients reviewed presented to the hospital within 8 h of symptom onset with a treatable large vessel occlusion (TIMI 0 or 1). The primary endpoint was the rate of successful recanalization as defined by TIMI scores of 2–3. Results: Mean baseline values at enrollment were age 65 years, median NIHSS score 18 (range 2–38), 61% were females, and the median time from symptom onset to arterial puncture was 5 h. After use of the Penumbra System, 91.8% of the treated vessels were revascularized to TIMI 2 or 3. Median time of aspiration was 18 min. Four procedural/device related SAEs were reported in three patients (5.4%). There were a total of 8 (10.8%) symptomatic ICHs reported at 24 h. At 90 days, all cause mortality was 23.0%. Of the 54 patients who either died or reached the 90 days follow-up, 20 (37.0%) had mRS scores of <2. Below are comparisons of the results in the ICA and MCA: Conclusions: These results suggest that in acute stroke patients with large vessel occlusion, the 054 reperfusion catheter is equi-effective in the reduction of clot burden in the ICA and MCA.