Two regimens of sultamicillin in treating uncomplicated gonorrhoea. Issue 1 (February 1985)

• Record Type: Journal Article
• Authors: Farthing, C; Thin, R N; Smith, S; Phillips, I
• Is Part Of: Sexually transmitted infections. Volume 61:Issue 1(1985)
• Page Start: 44
• Page End: 47
• Publication Date: 1985-02
• Subjects: Sexually transmitted diseases -- Periodicals; HIV infections -- Periodicals; 616.951005
• DOI: 10.1136/sti.61.1.44
• Languages: English
• ISSNs: 1368-4973

Abstract

Abstract : Sultamicillin is a covalent union of ampicillin and the beta lactamase inhibitor, sulbactam (CP-45, 899). Two studies were conducted to assess its efficacy in treating uncomplicated gonorrhoea. In the first study treatment comprised sultamicillin 1.5 g and probenecid 1 g; 124 (89.2%) of 139 patients responded including seven of 11 patients harbouring beta lactamase (penicillinase) producing strains of Neisseria gonorrhoeae (PPNG). In the second study sultamicillin 2.25 g and probenecid 1 g were given; 122 (93.8%) of 130 patients responded. Only two of seven pharyngeal infections resolved, and if pharyngeal infections are excluded the overall cure rate rose to 95.3%. Thirteen of 14 patients infected with PPNG strains were cured by the larger dose. Side effects were mild and transitory. It may be concluded that sultamicillin 2.25 g plus probenecid 1 g is an effective regimen to treat uncomplicated rectal and genital gonorrhoea and is useful for treating infections with PPNG strains. Most beta lactamase resistant antimicrobials must be given parenterally; sultamicillin is given by mouth.