Diabetes mellitus and latent tuberculosis infection: baseline analysis of a large UK cohort. Issue 1 (15th May 2018)

• Record Type: Journal Article
• Authors: Jackson, Charlotte; Southern, Jo; Lalvani, Ajit; Drobniewski, Francis; Griffiths, Chris J; Lipman, Marc; Bothamley, Graham H; Deeks, Jonathan J; Imran, Ambreen; Kon, Onn Min; Mpofu, Sithembinkosi; Nikolayevskyy, Vladyslav; Rees-Roberts, Melanie; Sitch, Alice; Sridhar, Saranya; Tsou, Chuen-Yan; Whitworth, Hilary; Abubakar, Ibrahim
• Is Part Of: Thorax. Volume 74:Issue 1(2019)
• Page Start: 91
• Page End: 94
• Publication Date: 2018-05-15
• Subjects: tuberculosis -- clinical epidemiology; Chest -- Diseases -- Periodicals; Thorax; Chest -- Diseases; Periodicals; Periodicals; 617.54
• DOI: 10.1136/thoraxjnl-2017-211124
• Languages: English
• ISSNs: 0040-6376

Abstract

Abstract : We conducted a cross-sectional analysis of baseline data from a UK cohort study which enrolled participants at risk of latent tuberculosis infection (LTBI, defined as a positive result for either of the two interferon gamma release assays). Binomial regression with a log link was used to estimate crude and adjusted prevalence ratios (PRs) and 95% CIs for the relationship between diabetes mellitus (DM) and LTBI. Adjusted for age, sex, ethnicity, body mass index and the presence of other immunocompromising conditions, DM was associated with a 15% higher prevalence of LTBI (adjusted PR=1.15, 95% CI 1.02 to 1.30, p=0.025). Trial registration number: PREDICT is registered on clinicaltrials.gov (NCT01162265 )