Genome-wide association studies in lung disease. Issue 3 (19th August 2011)

• Record Type: Journal Article
• Authors: Soler Artigas, María; Wain, Louise V; Tobin, Martin D
• Is Part Of: Thorax. Volume 67:Issue 3(2012)
• Page Start: 271
• Page End: 273
• Publication Date: 2011-08-19
• Subjects: Asthma genetics -- respiratory measurement -- COPD epidemiology -- clinical epidemiology -- COPD mechanisms -- asthma -- asthma mechanisms -- COPD exacerbations -- cough/mechanisms/pharmacology -- asthma guidelines -- cystic fibrosis -- exhaled airway markers -- lung physiology -- paediatric asthma -- paediatric lung disaese -- airway epithelium -- allergic lung disease -- cytokine biology -- eosinophil biology -- innate immunity -- lymphocyte biology -- airway epithelium -- allergic lung disease -- eosinophil biology -- asthma genetics -- respiratory measurement; Chest -- Diseases -- Periodicals; Thorax; Chest -- Diseases; Periodicals; Periodicals; 617.54
• DOI: 10.1136/thoraxjnl-2011-200724
• Languages: English
• ISSNs: 0040-6376

Abstract

Abstract : Genome-wide association studies (GWAS) have provided new insights into the molecular mechanisms of lung function and lung diseases. GWAS, and studies that build upon their findings, will continue to provide evidence aimed at advancing understanding of lung disease. This paper summarises the key features of a GWAS, references some recent findings and discusses how the chest physician can interpret the validity and utility of future GWAS and related studies.