Interrenal development and function in zebrafish. (15th September 2021)

• Record Type: Journal Article
• Authors: Bacila, Irina; Cunliffe, Vincent T.; Krone, Nils P.
• Is Part Of: Molecular and cellular endocrinology. Volume 535(2021)
• Publication Date: 2021-09-15
• Subjects: Zebrafish interrenal gland -- Steroid biosynthesis -- Steroidogenic enzymes -- Animal model -- Cortisol deficiency; Endocrinology -- Periodicals; Molecular biology -- Periodicals; Cytology -- Periodicals; Endocrinology -- Periodicals; Hormones -- Periodicals; Endocrinologie -- Périodiques; Cytology; Endocrinology; Molecular biology; Periodicals; 573.4
• DOI: 10.1016/j.mce.2021.111372
• Languages: English
• ISSNs: 0303-7207

Abstract

Abstract: In this article we aim to provide an overview of the zebrafish interrenal development and function, as well as a review of its contribution to basic and translational research. A search of the PubMed database identified 41 relevant papers published over the last 20 years. Based on the common themes identified, we discuss the organogenesis of the interrenal gland and its functional development and we review what is known about the genes involved in zebrafish steroidogenesis. We also outline the consequences of specific defects in steroid biosynthesis, as revealed by evidence from genetically engineered zebrafish models, including cyp11a2, cyp21a2, hsd3b1, cyp11c1 and fdx1b deficiency. Finally, we summarise the impact of different chemicals and environmental factors on steroidogenesis. Our review highlights the utility of zebrafish as a research model for exploring important areas of basic science and human disease, especially in the current context of rapid technological progress in the field of Molecular Biology. Highlights: Zebrafish is emerging as a research model in the study of adrenal pathophysiology and disease. The organogenesis and functional development of the zebrafish interrenal gland are established by day 5 after fertilisation. Established zebrafish models of steroidogenic enzyme deficiencies include cyp11a2, cyp21a2, hsd3b1, cyp11c1 and fdx1b .