Bacterial cellulose nanofibrils-reinforced composite hydrogels for mechanical compression-responsive on-demand drug release. (15th November 2021)

• Record Type: Journal Article
• Authors: Park, Daehwan; Kim, Joo Won; Shin, Kyounghee; Kim, Jin Woong
• Is Part Of: Carbohydrate polymers. Volume 272(2021)
• Publication Date: 2021-11-15
• Subjects: BC bacterial cellulose -- CNFs cellulose nanofibers BCNFs -- BCNFs bacterial cellulose nanofibers -- PAM polyacrylamide -- IPN interpenetrating network -- TEMPO 2, 2, 6, 6-tetramethylpiperidine-1-oxyl radical -- APS ammonium persulfate -- MBAA N, N-methylenebisacrylamide -- TMEDA N, N, N′, N′-tetramethylethylenediamine -- DPPC 1, 2-dipalmitoyl-sn-glycero-3-phosphocholine -- TEM transmission electron microscopy -- FT-IR Fourier transform infrared; Bacterial cellulose nanofibers -- Aspect ratio -- Semi-interpenetrating network -- On-demand drug delivery; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2021.118459
• Languages: English
• ISSNs: 0144-8617

Abstract

Abstract: Herein, we propose a cellulose-reinforced hybrid hydrogel system that not only increases mechanical strength, but also allows on-demand drug release. This hybrid hydrogel is specialized by its semi-interpenetrating network structure in which bacterial cellulose nanofibers (BCNFs) penetrate through a polyacrylamide (PAM) mesh. We showed that the interpenetrating BCNFs with a higher aspect ratio of 240 increased the compression strength of PAM/BCNF composite hydrogels approximately 3-fold, compared with that prepared with PAM only, stemming from the reinforcing effect of the rigid natural nanofibers between PAM meshes. We also observed that the swelling kinetics depended on the mechanical properties determined by the BCNF aspect ratio. From further studies on drug release, we demonstrated that the tailored composition of BCNFs with PAM retarded drug release by a factor of two compared to PAM only while enabling on-demand drug release in response to the applied compressive stress. These results highlight that our BCNFs-reinforced hydrogel system can be applied as a mechanical stress-responsive smart drug delivery patch. Highlights: A bacterial cellulose nanofibril (BCNF)-reinforced hydrogel system is reported. Mechanical properties of composite hydrogels are tuned by the aspect ratio of BCNFs. Our composite hydrogels show on-demand drug release in response to compressive stress.