MEG detection of high frequency oscillations and intracranial-EEG validation in pediatric epilepsy surgery. Issue 9 (September 2021)

• Record Type: Journal Article
• Authors: Foley, Elaine; Quitadamo, Lucia R.; Walsh, A. Richard; Bill, Peter; Hillebrand, Arjan; Seri, Stefano
• Is Part Of: Clinical neurophysiology. Volume 132:Issue 9(2021)
• Page Start: 2136
• Page End: 2145
• Publication Date: 2021-09
• Subjects: MEG -- Epilepsy -- HFOs -- Kurtosis -- Paediatric age -- iEEG -- Automatic detection -- Beamforming; Neurophysiology -- Periodicals; Electroencephalography -- Periodicals; Electromyography -- Periodicals; Neurology -- Periodicals; 612.8
• DOI: 10.1016/j.clinph.2021.06.005
• Languages: English
• ISSNs: 1388-2457

Abstract

Highlights: High frequency oscillations (HFOs) can be automatically detected in non-invasive MEG recordings from paediatric epilepsy patients. Sources of epileptic HFOs detected with MEG correspond well with sources of HFOs identified invasively from intracranial EEG recordings. Concordance of MEG HFO sources with seizure onset zone//resected area demonstrates potential to aid surgical planning in paediatric epilepsy. Abstract: Objective: To assess the feasibility of automatically detecting high frequency oscillations (HFOs) in magnetoencephalography (MEG) recordings in a group of ten paediatric epilepsy surgery patients who had undergone intracranial electroencephalography (iEEG). Methods: A beamforming source-analysis method was used to construct virtual sensors and an automatic algorithm was applied to detect HFOs (80–250 Hz). We evaluated the concordance of MEG findings with the sources of iEEG HFOs, the clinically defined seizure onset zone (SOZ), the location of resected brain structures, and with post-operative outcome. Results: In 8/9 patients there was good concordance between the sources of MEG HFOs and iEEG HFOs and the SOZ. Significantly more HFOs were detected in iEEG relative to MEG t(71) = 2.85, p < .05. There was good concordance between sources of MEG HFOs and the resected area in patients with good and poor outcome, however HFOs were also detected outside of the resected area in patients with poor outcome. Conclusion: Our findings demonstrate the feasibility of automatically detecting HFOs non-invasively in MEG recordings in paediatric patients, and confirm compatibility of results with invasive recordings. Significance: This approach provides support for the non-invasive detection of HFOs to aid surgical planning and potentially reduce the need for invasive monitoring, which is pertinent to paediatric patients.