D12 Longitudinal change in structural connectome in huntington's disease: the image-hd study. (13th September 2016)

• Record Type: Journal Article
• Authors: Georgiou-Karistianis, Nellie; Stout, Julie C; Churchyard, Andrew; Chua, Phyllis; Egan, Gary F; Poudel, Govinda
• Is Part Of: Journal of neurology, neurosurgery and psychiatry. Volume 87(2016)Supplement 1
• Page Start: A38
• Page End: A38
• Publication Date: 2016-09-13
• Subjects: longitudinal changes -- structural connectome -- imaging; Neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; Psychiatry -- Periodicals; 616.8
• DOI: 10.1136/jnnp-2016-314597.111
• Languages: English
• ISSNs: 0022-3050

Abstract

Abstract : Aims: To investigate 18 month longitudinal changes in structural connectome in pre-HD and symp-HD, compared with controls. Method: Longitudinal analysis of diffusion tensor imaging data was conducted for 28 pre-HD, 25 symp-HD, and 27 controls at baseline and 18 months. Unbiased tensor-based registration pipeline was used to register diffusion tensor data across time and groups. Whole brain probabilistic tractography was performed by seeding 50 million white-matter tracts (streamlines). The SIFT algorithm (spherical-deconvolution informed filtering of tractograms) removed bias in reconstructed tracts. 90x90 structural connectome was generated for each group. Longitudinal change in connectome was analysed using a Network Based Statistics analysis method and a group by time ANOVA model. Results: There was a significant within group change in structural connectivity in pre-HD and symp-HD (P < 0.05, FDR Corrected) but not controls. In pre-HD, longitudinal change was observed in two distinct networks: the first connected striatum with motor cortex and the second connected prefrontal cortex with parieto-occipital cortices. In symp-HD, longitudinal change was observed in widespread connexions between frontal and parietal cortices, and striatum and cortex. No distinct network-level changes were observed in symp-HD. Conclusions: Structural connectome analysis can capture network-specific structural disconnectivity. While connectivity change in symp-HD was diffuse overall, the pre-HD group showed distinct networks that changed over time. These connectional pathways offer new avenues to further investigate disease spread pathways in HD.