Antimicrobial and physicochemical characterization of 2, 3-dialdehyde cellulose-based wound dressings systems. (15th November 2021)

• Record Type: Journal Article
• Authors: Mayer, Sophie; Tallawi, Marwa; De Luca, Ilenia; Calarco, Anna; Reinhardt, Nikita; Gray, Luciano Avila; Drechsler, Klaus; Moeini, Arash; Germann, Natalie
• Is Part Of: Carbohydrate polymers. Volume 272(2021)
• Publication Date: 2021-11-15
• Subjects: Dialdehyde cellulose -- Bioactive films -- Wound dressing -- Antimicrobial -- Zein -- Gelatin; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2021.118506
• Languages: English
• ISSNs: 0144-8617

Abstract

Abstract: Biobased and biodegradable films were prepared by physically mixing 2, 3-dialdehyde cellulose (DAC) with two other biopolymers, zein and gelatin, in three different proportions. The antimicrobial activities of the composite blends against Gram-positive and Gram-negative bacteria increase with the increase of DAC content. Cell viability tests on mammalian cells showed that the materials were not cytotoxic. In addition, DAC and gelatin were able to promote thermal degradation of the blends. However, DAC increased the stiffness and decreased the glass transition temperature of the blends, while gelatin was able to decrease the stiffness of the film. Morphological analysis showed the effect of DAC on the surface smoothness of the blends. The contact angle confirmed that all blends were within the range of hydrophilic materials. Although all the blends showed impressive performance for wound dressing application, the blend with gelatin might be more suitable for this purpose due to its better mechanical performance and antibacterial activity. Highlights: Bio-based dialdehyde cellulose-zein films are suitable for wound dressing applications. Blends had antimicrobial activity against Gram-positive and Gram-negative bacteria. The systems showed very good viability and biocompatibility. Gelatin improved the DAC-Z blend's mechanical performance and antimicrobial activity.