Corchorus olitorius L. ameliorates alcoholic liver disease by regulating gut-liver axis. (October 2021)

• Record Type: Journal Article
• Authors: Do, Moon Ho; Lee, Hyun Hee L.; Kim, Yoonsook; Lee, Hye-Bin; Lee, Eunjung; Park, Jae Ho; Park, Ho-Young
• Is Part Of: Journal of functional foods. Volume 85(2021)
• Publication Date: 2021-10
• Subjects: Corchorus olitorius L. -- Molokhia -- Alcoholic liver disease -- Inflammation -- Lipid metabolism -- Gut microbiota; ACC acetyl-CoA carboxylase -- ALD alcohol liver disease -- ALT alanine aminotransferase -- AST aspartate aminotransferase -- ChREBP carbohydrate-responsive element-binding protein -- EtOH alcohol-consumption group -- FAS fatty acid synthase -- FITC-dextran dextran-fluorescein isothiocyanate -- GSH glutathione -- HPLC-ESI-MS high-performance liquid chromatography electrospray ionisation mass spectrometry -- IL-1β interleukin-1β -- LDH lactate dehydrogenase -- ORO Oil red O -- PC positive control -- SCD1 stearoyl-CoA desaturase-1 -- SREBP1 sterol regulatory element-binding protein 1 -- TG triglyceride -- TNF-α tumour necrosis factor-α -- WM water-soluble extract from molokhia (Corchorus olitorius L.) leaves; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2021.104648
• Languages: English
• ISSNs: 1756-4646

Abstract

Graphical abstract: Highlights: Water-soluble extract from molokhia leaves (WM) were extracted and characterized. WM ameliorates alcohol-induced metabolic disorder parameters. WM ameliorates alcohol-induced inflammation and lipid accumulation in liver. WM regulates gut microbial composition and ameliorates gut barrier function. Abstract: Gut microbial dysbiosis, induced by alcohol consumption, disrupts the gut-liver axis, leading to the development and progression of alcoholic liver disease. In this study, we investigated the protective effects of the water-soluble extract from molokhia ( Corchorus olitorius L.) leaves (WM) on the alcohol-induced disruption of the gut-liver axis in mice. The administration of 50 and 100 mg/kg WM reduced the levels of serum biomarkers for liver injury. Moreover, WM treatment ameliorated the alcohol-induced increase in hepatic inflammation and lipogenic protein levels. WM improved the gut microbial composition disrupted by alcohol, which suggests the effects of WM in mediating the gut-liver axis. WM also improved gut barrier function via the regulation of gut permeability and tight junction protein expression. These results indicate that WM can be used as a food supplement to improve alcohol-induced liver damage by regulating the gut-liver axis.