Development of Ga-68 radiolabeled DOTA functionalized and acetylated PAMAM dendrimer-coated iron oxide nanoparticles as PET/MR dual-modal imaging agent. Issue 15 (13th October 2021)

• Record Type: Journal Article
• Authors: Almasi, Tinoosh; Gholipour, Nazila; Akhlaghi, Mehdi; Mokhtari Kheirabadi, Amin; Mazidi, Seyed Mohammad; Hosseini, Seyed Hassan; Geramifar, Parham; Beiki, Davood; Rostampour, Nima; Shahbazi Gahrouei, Daryoush
• Is Part Of: International journal of polymeric materials. Volume 70:Issue 15(2021)
• Page Start: 1077
• Page End: 1089
• Publication Date: 2021-10-13
• Subjects: Gallium-68 -- iron oxide nanoparticles -- PET/MR imaging agent -- poly(amidoamide) dendrimer -- radiolabeling; Polymers -- Periodicals; Plastics -- Periodicals; 620.19205
• DOI: 10.1080/00914037.2020.1785451
• Languages: English
• ISSNs: 0091-4037

Abstract

Abstract: Gallium-68 radiolabeled DOTA- acetyl-PAMAM coated iron oxide nanoparticles (NPs) were developed as dual-modality agents for PET-MR imaging. The increase in the chelator content, acetylation step, and radiolabeling condition had distinctive effects on the physical, biological, and radiochemical properties of NPs. The r2 relaxivity coefficient value of the NPs was 96.7 mM −1 s −1 . High accumulation of candidate NPs was in the liver and spleen and about 3.4% ID/g uptake (tissue sampling), and a distinctive uptake (PET-CT image) were observed in the tumor site. These NPs could be used as the dual-modality agent for the diagnosis of the tumors via PET-MR imaging. Graphical Abstract: UF0001