Usefulness of hematopoietic progenitor cell monitoring to predict autologous peripheral blood stem cell harvest timing: A single-center retrospective study. (August 2021)

• Record Type: Journal Article
• Authors: Kasane, Moemi; Kurosawa, Saiko; Kojima, Minoru; Iwashita, Nao; Kase, Yuki; Tsubokura, Misato; Nakabayashi, Saori; Ikeda, Chiaki; Kawamura, Kimihiko; Matsushita, Hiromichi; Narita, Ryuichi; Fukumoto, Hidetomo; Fujino, Takahiro; Makita, Shinichi; Fukuhara, Suguru; Munakata, Wataru; Suzuki, Tatsuya; Maruyama, Dai; Ito, Ayumu; Tanaka, Takashi; Inamoto, Yoshihiro; Kim, Sung-Won; Tajima, Kinuko; Tanosaki, Ryuji; Izutsu, Koji; Fukuda, Takahiro
• Is Part Of: Transfusion and apheresis science. Volume 60:Number 4(2021)
• Publication Date: 2021-08
• Subjects: Hematopoietic progenitor cells -- HPC -- Autologous peripheral blood stem cell harvest -- APBSCH; Blood -- Transfusion -- Periodicals; Hemapheresis -- Periodicals; 615.39
• DOI: 10.1016/j.transci.2021.103150
• Languages: English
• ISSNs: 1473-0502

Abstract

Abstract: Introduction: In autologous peripheral blood stem cell harvest (APBSCH), CD34-positive cells have been measured to assess the numbers of hematopoietic stem cells, but measurement requires specialized equipment. Recently, there was a report that peripheral blood hematopoietic progenitor cells (HPCs) are useful indicators of the presence of hematopoietic stem cells. We examined the usefulness of HPC monitoring to predict APBSCH timing. Methods: We retrospectively analyzed the relationship between HPC and collected CD34-positive cells in 84 consecutive patients who underwent APBSCH. Results: According to the receiver operating characteristics curve for the collection of ≥2 × 106 CD34-positive cells/kg, the HPC cut-off value on the day before collection was 21/μL, while that on the day of collection was 41/μL. No significant factors were found in the univariate analysis except for the HPC count on the day before collection (p < 0.001) and the day of collection (p < 0.001). According to the multivariate analysis, the HPC count on the day before collection (p < 0.001) and the day of collection (p < 0.001) were also factors that strongly influenced the quantity of CD34-positive cells collected. Conclusion: Our results suggest that the HPC count on not only the day of collection but also the day before collection is a good indicator for appropriate APBSCH timing.