Practical Enzymatic Production of Carbocycles. Issue 46 (5th July 2021)

• Record Type: Journal Article
• Authors: Wang, Weijin; Taber, Douglass F.; Renata, Hans
• Is Part Of: Chemistry. Volume 27:Issue 46(2021)
• Page Start: 11773
• Page End: 11794
• Publication Date: 2021-07-05
• Subjects: alicyclic synthesis -- biocatalysis -- carbocycles -- enzymatic methods -- medicinal chemistry; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.202101232
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract: The Pd‐catalyzed carbon‐carbon bond formation pioneered by Heck in 1969 has dominated medicinal chemistry development for the ensuing fifty years. As the demand for more complex three‐dimensional active pharmaceuticals continues to increase, preparative enzyme‐mediated assembly, by virtue of its exquisite selectivity and sustainable nature, is poised to provide a practical and affordable alternative for accessing such compounds. In this minireview, we summarize recent state‐of‐the‐art developments in practical enzyme‐mediated assembly of carbocycles. When appropriate, background information on the enzymatic transformation is provided and challenges and/or limitations are also highlighted. Abstract : Recent years have witnessed a rapid growth of biocatalytic methods in organic synthesis. This Minireview summarizes the developments in the current state of the art for practical enzyme‐mediated assembly of carbocycles, drawing special attention to case studies that have been performed on preparative scale.