Serum concentrations of organochlorine pesticides, biomarkers of oxidative stress, and risk of breast cancer. (1st October 2021)

• Record Type: Journal Article
• Authors: Miao, Yu; Rong, Mao; Li, Min; He, Heng; Zhang, Li; Zhang, Shanshan; Liu, Chong; Zhu, Ying; Deng, Yan-Ling; Chen, Pan-Pan; Zeng, Jia-Yue; Zhong, Rong; Mei, Su-Rong; Miao, Xiao-Ping; Zeng, Qiang
• Is Part Of: Environmental pollution. Volume 286(2021)
• Publication Date: 2021-10-01
• Subjects: Breast cancer -- Endocrine disrupting chemicals -- Mediation -- Organochlorine pesticides -- Oxidative stress; Pollution -- Periodicals; Pollution -- Environmental aspects -- Periodicals; Environmental Pollution -- Periodicals; Pollution -- Périodiques; Pollution -- Aspect de l'environnement -- Périodiques; Pollution -- Effets physiologiques -- Périodiques; Pollution; Pollution -- Environmental aspects; Periodicals; Electronic journals; 363.73
• DOI: 10.1016/j.envpol.2021.117386
• Languages: English
• ISSNs: 0269-7491

Abstract

Abstract: Studies have documented that exposure to organochlorine pesticides (OCPs) is linked with breast cancer, but the underlying biological mechanisms are still unknown. This study included 313 women diagnosed with breast cancer and 313 controls in Wuhan, China, and measured 18 OCPs in serum and 3 oxidative stress biomarkers in urine. Multivariable adjusted regression models were used to evaluate the associations among OCPs, oxidative stress biomarkers, and breast cancer. The mediating effect of oxidative stress was assessed by mediation analysis. We observed that most OCPs were positively associated with risk of breast cancer (all FDR-P values < 0.05 or 0.10). Moreover, we found that p, p'-DDT, p, p'-DDD, dieldrin, heptachlor, and heptachlor epoxide were positively associated with 4-hydroxy-2-nonenal-mercapturic acid (HNE-MA) and 8-iso-prostaglandin F2α (8-isoPGF2α ), which in turn were positively associated with risk of breast cancer. Mediation analysis indicated that HNE-MA and 8-isoPGF2ɑ mediated the positive associations between these OCPs and risk of breast cancer, with mediating proportion ranging from 6.23% to 19.9%. Our results suggest that lipid peroxidation may mediate the positive associations between OCP exposures and risk of breast cancer. Graphical abstract: Image 1 Highlights: Most serum OCPs were positively associated with breast cancer. Multiple serum OCPs were positively associated with urinary HNE-MA and 8-isoPGF2ɑ. Urinary HNE-MA and 8-isoPGF2ɑ were positively associated with breast cancer. HNE-MA and 8-isoPGF2ɑ mediated the associations between OCPs and breast cancer. Abstract : Lipid peroxidation may mediate the positive associations between organochlorine pesticide exposures and risk of breast cancer.