Cord serum elementomics profiling of 56 elements depicts risk of preterm birth: Evidence from a prospective birth cohort in rural Bangladesh. (November 2021)

• Record Type: Journal Article
• Authors: Huang, Hui; Wei, Liangmin; Chen, Xin; Zhang, Ruyang; Su, Li; Rahman, Mahmudur; Golam Mostofa, Md.; Qamruzzaman, Quazi; Zhao, Yang; Yu, Hao; Wei, Yongyue; Christiani, David C.; Chen, Feng
• Is Part Of: Environment international. Volume 156(2021)
• Publication Date: 2021-11
• Subjects: Element exposure -- Mixtures -- Preterm birth -- Inductively coupled plasma mass spectrometry -- Bangladesh; BMI Body mass index -- CV Coefficient of variation -- FDR False discovery rate -- ICP-MS Inductively coupled plasma mass spectrometry -- LOD Limit of detection -- OR Odds ratio -- 7Li Lithium -- 9Be Beryllium -- 11B Boron -- 23Na Sodium -- 24Mg Magnesium -- 27Al Aluminum -- 39K Potassium -- 44Ca Calcium -- 45Sc Scandium -- 47Ti Thallium -- 51V Vanadium -- 52Cr Chromium -- 55Mn Manganese -- 56Fe Iron -- 59Co Cobalt -- 60Ni Nickel -- 63Cu Copper -- 66Zn Zinc -- 71Ga Gallium -- 75As Arsenic -- 78Se Selenium -- 85Rb Rubidium -- 88Sr Strontium -- 89Y Yttrium -- 90Zr Zirconium -- 93Nb Niobium -- 95Mo Molybdenum -- 107Ag Silver -- 111Cd Cadmium -- 118Sn Tin -- 121Sb Antimony -- 133Cs Cesium -- 137Ba Barium -- 139La Lanthanum -- 140Ce Cerium -- 141Pr Praseodymium -- 146Nd Neodymium -- 147Sm Samarium -- 151Eu Europium -- 159Tb Terbium -- 163Dy Dysprosium -- 165Ho Holmium -- 166Er Erbium -- 169Tm Thulium -- 172Yb Ytterbium -- 175Lu Lutetium -- 178Hf Hafnium -- 181Ta Tantalum -- 182W Wolfram -- 202Hg Hydrargyrum -- 208Pb Lead -- 209Bi Bismuth -- 232Th Thorium -- 238U Uranium -- 95% CI 95% Confidence interval; Environmental protection -- Periodicals; Environmental health -- Periodicals; Environmental monitoring -- Periodicals; Environmental Monitoring -- Periodicals; Environnement -- Protection -- Périodiques; Hygiène du milieu -- Périodiques; Environnement -- Surveillance -- Périodiques; Environmental health; Environmental monitoring; Environmental protection; Periodicals; 333.705
• DOI: 10.1016/j.envint.2021.106731
• Languages: English
• ISSNs: 0160-4120

Abstract

Highlights: This study assessed the most comprehensive exposure of 56 elements in Bangladesh. Cord blood Ti, As, and Ba were associated with increased risk of preterm birth. The effect of element mixtures may play an important role in preterm birth. Mothers with history of child marriage may be a high-risk group for element exposure. Abstract: Maternal exposure to some individual rare earth elements and trace elements is associated with preterm birth, but few elements have been studied and little is known about the potential effect of simultaneous exposure to multiple elements. We examined individual and mixture effects of elements on preterm birth among 745 pregnant women in a prospective birth cohort in Bangladesh (2008–2011). We measured 56 elements in umbilical cord blood collected during delivery using inductively coupled plasma-mass spectrometry. Using elastic net (ENET) regularization and multivariate logistic regression, we examined independent associations between element concentrations and preterm birth. Bayesian kernel machine regression identified mixture effects of elements most critical to preterm birth, accounting for correlated exposure and interaction. ENET identified titanium (Ti), arsenic (As), and barium (Ba) as the most important predictors of shortened gestational age and preterm birth. In adjusted models, cord blood Ti (OR = 2.52; 95% CI: 1.08–5.93; P = 0.033), As (odds ratio (OR) = 1.34; 95% CI: 1.04–1.73; P = 0.023), and Ba (OR = 1.18; 95% CI: 1.02–1.38; P = 0.029) were significantly associated with preterm birth. Bayesian kernel machine regression suggested an interaction effect between As and Ba. Further, we constructed an element risk score (ERS) using estimated weights from a multivariate regression model for Ti, As, and Ba and regressed preterm birth by this score (OR = 2.72, 95% CI: 1.57–4.69; P = 3.35 × 10 -4 ). Additionally, we observed a significant modification effect of child marriage on ERS, which means marriage before the age of 18 ( P interaction = 0.0438). This study identified element exposures profiles in cord blood and constructed metal risk score that are jointly associated with the risk of preterm birth. Ti, As, and Ba exposure may adversely affect birth outcomes as well as child marriage may be a modifiable factor potentially affecting environmental element exposure and preterm birth.