Decellularized xenografts in regenerative medicine: From processing to clinical application. (12th March 2021)

• Record Type: Journal Article
• Authors: Capella‐Monsonís, Héctor; Zeugolis, Dimitrios I.
• Is Part Of: Xenotransplantation. Volume 28:Number 4(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-03-12
• Subjects: biomaterials -- clinical products -- decellularized xenografts -- extracellular matrix; Xenografts -- Periodicals; Transplantation of organs, tissues, etc -- Periodicals; 617.95
• DOI: 10.1111/xen.12683
• Languages: English
• ISSNs: 0908-665X

Abstract

Abstract: Decellularized xenografts are an inherent component of regenerative medicine. Their preserved structure, mechanical integrity and biofunctional composition have well established them in reparative medicine for a diverse range of clinical indications. Nonetheless, their performance is highly influenced by their source (ie species, age, tissue) and processing (ie decellularization, crosslinking, sterilization and preservation), which govern their final characteristics and determine their success or failure for a specific clinical target. In this review, we provide an overview of the different sources and processing methods used in decellularized xenografts fabrication and discuss their effect on the clinical performance of commercially available decellularized xenografts.