Schwann cell interactions during the development of the peripheral nervous system. Issue 5 (5th May 2020)

• Record Type: Journal Article
• Authors: Wilson, Emma R.; Della‐Flora Nunes, Gustavo; Weaver, Michael R.; Frick, Luciana R.; Feltri, M. Laura
• Is Part Of: Developmental neurobiology. Volume 81:Issue 5(2021)
• Page Start: 464
• Page End: 489
• Publication Date: 2020-05-05
• Subjects: axo‐glial communication -- axon -- glia -- myelin -- peripheral nerve; Neurobiology -- Periodicals; Neurobiology; Neurobiologie -- Périodiques; Neurobiology; Periodicals; Periodicals; 573.838
• DOI: 10.1002/dneu.22744
• Languages: English
• ISSNs: 1932-8451

Abstract

Abstract: Schwann cells play a critical role in the development of the peripheral nervous system (PNS), establishing important relationships both with the extracellular milieu and other cell types, particularly neurons. In this review, we discuss various Schwann cell interactions integral to the proper establishment, spatial arrangement, and function of the PNS. We include signals that cascade onto Schwann cells from axons and from the extracellular matrix, bidirectional signals that help to establish the axo‐glial relationship and how Schwann cells in turn support the axon. Further, we speculate on how Schwann cell interactions with other components of the developing PNS ultimately promote the complete construction of the peripheral nerve.