A ten‐year surveillance of P aeruginosa bloodstream infections in a tertiary care hospital: Trends and risk factors for mortality. Issue 9 (7th June 2021)

• Record Type: Journal Article
• Authors: Ababneh, Mera A.; Rababa'h, Abeer M.; Almomani, Basima A.; Ayoub, Abeer M.; Al‐Azzam, Sayer I.
• Is Part Of: International journal of clinical practice. Volume 75:Issue 9(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-06-07
• Subjects: Clinical medicine -- Periodicals; Medicine -- Periodicals; 610.5
• DOI: 10.1111/ijcp.14409
• Languages: English
• ISSNs: 1368-5031

Abstract

Abstract: Background: Pseudomonas aeruginosa ( P aeruginosa ) is a leading cause of nosocomial bloodstream infections worldwide. This study aimed to evaluate the incidence of P aeruginosa bloodstream infections and to identify predictors of 30‐day mortality. Methods: A retrospective study was conducted in an academic tertiary hospital in Jordan. The medical records of patients hospitalised over ten years (1 January 2008‐31 December 2017) were reviewed to identify patients' positive blood culture of P aeruginosa . Annual incidence, antimicrobial susceptibility patterns and risk factors for 30‐day mortality were analysed. Results: A total of 169 cases of P aeruginosa bloodstream infection were identified, with an overall incidence rate of 0.23 case/1000 admission. The overall crude 30‐day mortality was 36.7%. Receipt of corticosteroids (OR = 4.5; P = .0017), severe sepsis and septic shock (OR = 2.7; P = .0476), admission to intensive care unit (OR = 5.9; P = .0004), end‐stage renal disease (OR = 4.1; P = .0123), inappropriate empirical therapy (OR = 3.2; P = .0143) and inappropriate definitive therapy (OR = 2.9; P = .0110) were identified as independent risk factors for mortality. Conclusion: The annual incidence of P aeruginosa BSIs was fluctuating over ten years period. Several predictors for 30‐day mortality in patients with P aeruginosa BSIs were identified, including inappropriate empirical and definitive therapy.