Linking minimal and detailed models of CA1 microcircuits reveals how theta rhythms emerge and their frequencies controlled. Issue 9 (4th June 2021)

• Record Type: Journal Article
• Authors: Chatzikalymniou, Alexandra Pierri; Gumus, Melisa; Skinner, Frances K.
• Is Part Of: Hippocampus. Volume 31:Issue 9(2021)
• Page Start: 982
• Page End: 1002
• Publication Date: 2021-06-04
• Subjects: CA1 microcircuit -- interneuron -- mathematical model -- network -- theta rhythm; Hippocampus (Brain) -- Periodicals; 612.825
• DOI: 10.1002/hipo.23364
• Languages: English
• ISSNs: 1050-9631

Abstract

Abstract: The wide variety of cell types and their biophysical complexities pose a challenge in our ability to understand oscillatory activities produced by cellular‐based computational network models. This challenge stems from their high‐dimensional and multiparametric natures. To overcome this, we implement a solution by linking minimal and detailed models of CA1 microcircuits that generate intrahippocampal (3–12 Hz) theta rhythms. We leverage insights from minimal models to guide explorations of more detailed models and obtain a cellular perspective of theta generation. Our findings distinguish the pyramidal cells as the theta rhythm initiators and reveal that their activity is regularized by the inhibitory cell populations, supporting a proposed hypothesis of an "inhibition‐based tuning" mechanism. We find a strong correlation between input current to the pyramidal cells and the resulting local field potential theta frequency, indicating that intrinsic pyramidal cell properties underpin network frequency characteristics. This work provides a cellular‐based foundation from which in vivo theta activities can be explored.