Comparison of 68Ga-DOTA-FAPI and 18FDG PET/CT imaging modalities in the detection of liver metastases in patients with gastrointestinal system cancer. Issue 142 (September 2021)

• Record Type: Journal Article
• Authors: Şahin, Ertan; Elboğa, Umut; Çelen, Yusuf Zeki; Sever, Özlem Nuray; Çayırlı, Yusuf Burak; Çimen, Ufuk
• Is Part Of: European journal of radiology. Issue 142(2021)
• Publication Date: 2021-09
• Subjects: Gastrointestinal system cancer -- Liver metastasis -- 18FDG-PET/CT -- 68Ga-DOTATA-FAPI-PET/CT; Medical radiology -- Periodicals; Radiology -- Periodicals; Radiologie médicale -- Périodiques; Medical radiology; Periodicals; 616.075705
• DOI: 10.1016/j.ejrad.2021.109867
• Languages: English
• ISSNs: 0720-048X

Abstract

Abstract: Purpose: We aimed to compare the diagnostic performance of PET/CT imaging performed with 68 Ga-DOTA-FAPI and 18 FDG in detection of liver metastases in patients with gastrointestinal system (GIS) cancer. Methods: A total of 31 patients who underwent 68 Ga-DOTA-FAPI and 18 F-FDG PET/CT examinations and diagnosed with GIS cancer (15 colorectal, 9 pancreas, 4 stomach and 3 other cancers) were included in the study. The presence of liver metastasis was decided based on histopathologic diagnosis, PET/CT, other radiologic examinations or tumor biomarker findings, and both PET/CT imaging findings were compared on the patient and lesion basis. Results: Of the 31 patients, 28 were found as true positive with 68 Ga-DOTA-FAPI-PET/CT and 17 with 18 FDG-PET/CT. Of the 98 metastatic liver lesions determined according to our diagnostic criteria, 92 were found as true positive lesions with 68 Ga-DOTA-FAPI-PET/CT and 65 with 18 FDG-PET/CT. There was a statistically significant difference between both imaging modalities in the patient and lesion based comparisons (p < 0.05). When semiquantitative values (SUVmax, mlr) obtained from the lesions were compared between the two imaging methods, mlr values showed statistically significant difference in all tumor subgroups (p < 0.05). Conclusion: It was concluded that 68 Ga-DOTA-FAPI-PET/CT was superior over 18 FDG-PET/CT in detection of liver metastases of GIS cancers and it can be a complementary method especially in negative cases with 18 FDG-PET/CT.