Caffeic acid and its derivatives as potential modulators of oncogenic molecular pathways: New hope in the fight against cancer. (September 2021)

• Record Type: Journal Article
• Authors: Mirzaei, Sepideh; Gholami, Mohammad Hossein; Zabolian, Amirhossein; Saleki, Hossein; Farahani, Mahdi Vasheghani; Hamzehlou, Soodeh; Far, Fatemeh Bakhtiari; Sharifzadeh, Seyed Omid; Samarghandian, Saeed; Khan, Haroon; Aref, Amir Reza; Ashrafizadeh, Milad; Zarrabi, Ali; Sethi, Gautam
• Is Part Of: Pharmacological research. Volume 171(2021)
• Publication Date: 2021-09
• Subjects: CA caffeic acid -- CAPE caffeic acid phenethyl ester -- BBB blood-brain barrier -- LPO lipid peroxidation -- GSH glutathione -- GPx glutathione peroxidase -- SOD superoxide dismutase -- MDA malondialdehyde -- UGT UDP-glucuronosyltransferse -- DCA decyl CA -- SPIONs superparamagnetic iron oxide nanoparticles -- Akt protein kinase-B -- STAT3 signal transducer and activator of transcription 3 -- AMPK AMP-activated protein kinase -- siRNA small interfering RNA -- PCD programmed cell death -- TNF tumor necrosis factor -- IAP inhibitor of apoptosis -- EMT epithelial-to-mesenchymal transition -- NF-κB nuclear factor-kappaB -- VEGF vascular endothelial growth factor -- VEGFR2 VEGF receptor-2 -- TSP thrombospondins -- ES endostatin -- ECM extracellular matrix -- MMPs matrix metalloproteinases -- RT radiation therapy -- CP cisplatin -- Nrf2 nuclear factor erythroid 2-related factor 2 -- PTX paclitaxel -- DTX docetaxel -- IGF1R insulin-like growth factor-1 receptor -- FOXO1 forkhead box O1 -- ER estrogen receptor -- NSCLC non-small cell lung cancer -- JNK c-Jun N-terminal kinase -- ERK extracellular-signal regulated kinase -- DOX doxorubicin -- MDR multidrug resistance -- ABC ATP-binding cassette -- FA fatty acid -- PI3K phosphoinositide 3-kinase -- CAPPE caffeic acid phenylpropyl ester -- CSCs cancer stem cells -- GSK-3β glycogen synthase kinase-3beta -- FGF18 fibroblast growth factor 18 -- EGFR epidermal growth factor receptor -- NDRG N-myc downstream-regulated gene -- TGF-β transforming growth factor-beta -- FANCD2 Fanconi Anemia D2 -- TIMP1 TIMP Metalloproteinase Inhibitor 1 -- HIF-1α hypoxia inducible factor-1α -- TCA tricarboxylic acid -- POX proline oxidase -- PRODH proline metabolism and proline dehydrogenase -- PgR progesterone receptor -- Au gold -- EPR enhanced permeability and retention -- SLNPs solid lipid nanoparticles; Caffeic acid -- Cancer therapy -- Medicinal plants -- Apoptosis -- Autophagy -- Chemotherapy; Pharmacology -- Periodicals; Pharmacology -- Periodicals; Research -- Periodicals; Médicaments -- Recherche -- Périodiques; Pharmacologie -- Périodiques; 615.105
• DOI: 10.1016/j.phrs.2021.105759
• Languages: English
• ISSNs: 1043-6618

Abstract

Abstract: As a phenolic acid compound, caffeic acid (CA) can be isolated from different sources such as tea, wine and coffee. Caffeic acid phenethyl ester (CAPE) is naturally occurring derivative of CA isolated from propolis. This medicinal plant is well-known due to its significant therapeutic impact including its effectiveness as hepatoprotective, neuroprotective and anti-diabetic agent. Among them, anti-tumor activity of CA has attracted much attention, and this potential has been confirmed both in vitro and in vivo. CA can induce apoptosis in cancer cells via enhancing ROS levels and impairing mitochondrial function. Molecular pathways such as PI3K/Akt and AMPK with role in cancer progression, are affected by CA and its derivatives in cancer therapy. CA is advantageous in reducing aggressive behavior of tumors via suppressing metastasis by inhibiting epithelial-to-mesenchymal transition mechanism. Noteworthy, CA and CAPE can promote response of cancer cells to chemotherapy, and sensitize them to chemotherapy-mediated cell death. In order to improve capacity of CA and CAPE in cancer suppression, it has been co-administered with other anti-tumor compounds such as gallic acid and p-coumaric acid. Due to its poor bioavailability, nanocarriers have been developed for enhancing its ability in cancer suppression. These issues have been discussed in the present review with a focus on molecular pathways to pave the way for rapid translation of CA for clinical use. Graphical Abstract: ga1 Highlights: Caffeic acid (CA) is a member of phenolic acid family of polyphenols. CA and its derivatives can induce both apoptosis and autophagy in cancer cells. CA and its derivatives impair migration and metastasis of cancer cells. CA and its derivatives promote radio- and chemo-sensitivity of cancer cells. Nanoparticles promote therapeutic effect of CA and CAPE in reducing cancer cell malignancy.