P I – 2–8 Early-life exposure to persistent organic pollutants and attention-deficit/hyperactivity disorder: a multi-pollutant assessment of a norwegian birth cohort. (18th March 2018)

• Record Type: Journal Article
• Authors: Lenters, Virissa; Čechová, Eliška; Kočan, Anton; Legler, Juliette; Leonards, Pim; Forns, Joan; Iszatt, Nina; Stigum, Hein; Eggesbø, Merete
• Is Part Of: Occupational and environmental medicine. Volume 75(2018)Supplement 1
• Page Start: A34
• Page End: A35
• Publication Date: 2018-03-18
• Subjects: Medicine, Industrial -- Periodicals; Environmental health -- Periodicals; 616.980305
• DOI: 10.1136/oemed-2018-ISEEabstracts.85
• Languages: English
• ISSNs: 1351-0711

Abstract

Abstract : Background/aim: Numerous ubiquitous environmental chemicals are established or suspected neurotoxicants, and infants are exposed to a mixture of these during the critical period of brain maturation. Evidence for associations with the risk of attention-deficit/hyperactivity disorder (ADHD) is sparse. We investigated measured perinatal and estimated postnatal chemical exposure levels in relation to ADHD. Methods: We used a birth cohort of Norwegian mother–child pairs enrolled 2005–2009 (HUMIS-NoMIC). In a subset of 1199 oversampled for neurodevelopmental outcomes, 27 persistent organic pollutants were measured in maternal breastmilk samples (14 PCBs, 5 organochlorine pesticides, 6 brominated flame retardants, and 2 perfluoroalkyl substances). We modelled pre- and postnatal exposures using a pharmacokinetic model. ADHD (n=40) was identified based on an ICD-10 diagnosis of hyperkinetic disorder in the national patient registry by 2014 (median age of 10.3 years). To identify associations and adjust for co-exposure confounding, we used elastic net penalised logistic regression models, and then used multivariable logistic regression models to obtain effect estimates for the selected exposures. Results: Perfluorooctane sulfonate (PFOS) and β -hexachlorocyclohexane ( β -HCH) were associated with increased odds and hexachlorobenzene (HCB) with decreased odds of ADHD diagnosis [confounder-adjusted odds ratio (OR) per interquartile range increase in breastmilk levels: 2.04 for PFOS; OR=1.64 for β -HCH; OR=0.36 for HCB]. Postnatal exposures showed similar results, whereas effect estimates for other chemicals were imprecise. Conclusion: In a multi-pollutant analysis of four classes of chemicals, early-life exposure to several persistent organic pollutants was associated with ADHD.