Resting-state fMRI study on drug-naive patients with Parkinson's disease and with depression. Issue 6 (13th November 2013)

• Record Type: Journal Article
• Authors: Luo, ChunYan; Chen, Qin; Song, Wei; Chen, Ke; Guo, XiaoYan; Yang, Jing; Huang, XiaoQi; Gong, QiYong; Shang, Hui-Fang
• Is Part Of: Journal of neurology, neurosurgery and psychiatry. Volume 85:Issue 6(2014)
• Page Start: 675
• Page End: 683
• Publication Date: 2013-11-13
• Subjects: Parkinson's Disease -- Depression -- Functional Imaging; Neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; Psychiatry -- Periodicals; 616.8
• DOI: 10.1136/jnnp-2013-306237
• Languages: English
• ISSNs: 0022-3050

Abstract

Abstract : Objective: This study used resting-state functional MRI (fMRI) to evaluate regional and network alterations in patients with Parkinson's disease (PD) with and without depression. Method: We recruited 29 patients with PD with depression (PD-Dep), 30 patients with PD without depression (PD-NDep), and 30 normal controls. All participants underwent resting-state fMRI scans on a 3-T MR system. The amplitude of low-frequency fluctuation (ALFF) of blood oxygen level-dependent signals was used to characterise regional cerebral function. Functional integration of the brain network was evaluated by seed-based correlation approach. Results: The PD-Dep group showed significantly higher ALFF value in the left orbitofrontal area compared with both the PD-NDep and control groups (p<0.05 corrected by FWE). In patients with PD, the Hamilton Depression Rating Scale score was positively correlated with the ALFF value in the left orbitofrontal cortex (p<0.005 uncorrected). Brain network connectivity analysis revealed reduced functional connectivity of putamen in both PD subgroups. However, the PD-Dep group showed more distributed reduced connectivity in the prefrontal-limbic network than the PD-NDep group did (p<0.05 corrected by FWE). Conclusions: Our study demonstrates that PD-Dep patients are characterised by increased regional spontaneous neural activity in the orbitofrontal area and decreased functional integration within the prefrontal-limbic network. These findings may be helpful for facilitating further understanding of the potential mechanisms underlying depression in PD.