HHV-8-negative multicentric Castleman disease presenting as a crescentic immune complexes membranoproliferative glomerulonephritis. Issue 1 (6th January 2020)

• Record Type: Journal Article
• Authors: Nunes, Maria Brito; Rotman, Samuel; Duss, Francois-Regis; Halfon, Matthieu
• Is Part Of: BMJ case reports. Volume 13:Issue 1(2020)
• Publication Date: 2020-01-06
• Subjects: acute renal failure -- proteinurea; Medicine -- Case studies -- Periodicals; 610.5
• DOI: 10.1136/bcr-2019-231844
• Languages: English
• ISSNs: 1757-790X

Abstract

Abstract : Multicentric Castleman disease is a rare polyclonal lymphoproliferative disorder mainly associated with two renal manifestations: thrombotic microangiopathy and amyloidosis. Nevertheless, we report here a case of human herpes virus-8 negative multicentric Castleman disease with membranous proliferative glomerulonephritis and extracapillary proliferation. A patient was successfully treated with corticosteroids, anti-CD20 and cyclophosphamide therapy.