Mesenteric infarction due to combined protein C deficiency and prothrombin 20210 defects. Issue 890 (1st December 1999)

• Record Type: Journal Article
• Authors: Mainwaring, C J; Makris, M; Thomas, W E G; Hampton, K K; Preston, F E
• Is Part Of: Postgraduate medical journal. Volume 75:Issue 890(1999)
• Page Start: 742
• Page End: 743
• Publication Date: 1999-12-01
• Subjects: mesenteric venous infarction -- protein C deficiency -- prothrombin 20210A; Medicine -- Periodicals; 610
• DOI: 10.1136/pgmj.75.890.742
• Languages: English
• ISSNs: 0032-5473

Abstract

Abstract : The prothrombin gene mutation, 20210A, a guanine to adenine substitution at nucleotide position 20210, has recently been described as an additional risk factor for venous thromboembolic disease. We describe the case of a patient with combined heterozygous prothrombin 20210A mutation and type 1 protein C deficiency who presented with massive mesenteric venous infarction of his small bowel and survived following the use of protein C concentrate and extensive small bowel resection.