Experimental ulcerative herpetic keratitis. II. Influence of topical corticosteroid in immunised rabbits. Issue 6 (June 1981)

• Record Type: Journal Article
• Authors: Carter, C A; Easty, D L; Walker, S R
• Is Part Of: British journal of ophthalmology. Volume 65:Issue 6(1981)
• Page Start: 388
• Page End: 391
• Publication Date: 1981-06
• Subjects: Ophthalmology -- Periodicals; 617.7
• DOI: 10.1136/bjo.65.6.388
• Languages: English
• ISSNs: 0007-1161

Abstract

Abstract : Since the great majority of patients possess immune response to herpes simplex virus (HSV), the influence of a topical anti-inflammatory corticosteroid (0.1% clobetasone butyrate) on ulcerative herpetic keratitis was studied in rabbits with a previous HSV skin infection (immunised) and compared with that in normal rabbits. Corticosteroid treatment had a much greater ulceration-exacerbating effect in immunised than in normal animals. On day 7 the mean area of ulceration in immunised rabbits were 3 times greater in treated eyes. 0.01% clobetasone butyrate treatment had less effect on immunised rabbits; 0.001% had no effect. It is concluded that the immunised rabbit provides a useful experimental model for studying the relationship between concentration of topical anti-inflammatory agents and enhancement of herpetic ulceration.