Cerebrospinal fluid neuron-specific enolase is decreased in multi-infarct dementia, but unchanged in Alzheimer's disease. Issue 4 (April 1988)

• Record Type: Journal Article
• Authors: Sulkava, R; Viinikka, L; Erkinjuntti, T; Roine, R
• Is Part Of: Journal of neurology, neurosurgery and psychiatry. Volume 51:Issue 4(1988)
• Page Start: 549
• Page End: 551
• Publication Date: 1988-04
• Subjects: Neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; Psychiatry -- Periodicals; 616.8
• DOI: 10.1136/jnnp.51.4.549
• Languages: English
• ISSNs: 0022-3050

Abstract

Abstract : Cerebrospinal fluid (CSF) levels of neuron-specific enolase (NSE) were measured in 22 patients with probable Alzheimer's disease and in 35 patients with multi-infarct dementia, and in 15 controls. CSF NSE in patients with Alzheimer's disease did not differ from those in controls. In patients with multi-infarct dementia without recent vascular events CSF NSE was lower than in controls or in Alzheimer patients. This finding is in accord with the prevailing opinion that vascular dementia is caused by multiple infarcts and not by continuous neuronal ischaemia.