Biological findings in Von Willebrand's pedigrees: implications for inheritance. Issue 2 (March 1967)

• Record Type: Journal Article
• Authors: Meyer, Dominique; Larrieu, Marie-José; Maroteaux, Pierre; Caen, Jacques P.
• Is Part Of: Journal of clinical pathology. Volume 20:Issue 2(1967)
• Page Start: 190
• Page End: 194
• Publication Date: 1967-03
• Subjects: Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jcp.20.2.190
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : Thirty-one subjects from three families affected by Von Willebrand's disease have been investigated with the following tests: Ivy's bleeding time; platelet adhesiveness according to Salzman; two-stage factor VIII assay. Twelve patients have a complete form of the disease, i.e., a prolonged bleeding time with low platelet adhesiveness, and a reduced factor VIII level. Eight subjects have an isolated low platelet adhesiveness associated in three cases with a prolonged bleeding time. The low platelet adhesiveness in these subjects was corrected, as in Von Willebrand's disease, by infusion of haemophilia A plasma. The dominant autosomal mode of inheritance appears to be due to a pleiotropic gene, expressed in a variety of ways